Reducing systemic toxicity in local tumor gene therapy using an alginate solution

Yong Wang, Jim Kang Hu, Ava Krol, Yong Ping Li, Chuan Yuan Li, Fan Yuan

Research output: Contribution to journalConference article

Abstract

To reduce dissemination of viral vectors and their gene products during and after local gene therapy, we mixed adenoviral vectors with an alginate solution and subsequently injected the mixture into mouse tumors. We found that the alginate solution significantly reduced the dissemination of adenoviral vectors for EGFP and IL-12 into the liver and the IL-12 concentration in the serum. On the other hand, the alginate solution had no effects on EGFP and IL-12 expressions in tumors as well as the growth of IL-12 vector treated tumors.

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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