Reduction in brain serotonin markers by α-ethyltryptamine (Monase)

Xuemei Huang; Michael P. Johnson; David E. Nichols

doi:10.1016/0014-2999(91)90686-K

Reduction in brain serotonin markers by α-ethyltryptamine (Monase)

Xuemei Huang, Michael P. Johnson, David E. Nichols

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

α-Ethyltryptamine (Monase) is both an inhibitor of monoamine oxidase and a monoamine releasing agent. To determine whether α-ethyltryptamine induces serotonergic deficits similar to that of other monoamine releasing agents such as 3,4-methyl-enedioxymethamphetamine (MDMA) and para-chloroamphetamine (PCA), rats were given multiple doses (8 × 30 mg/kg s.c.) of α-ethyltryptamine acetate. Serotonin and 5-hydroxyindole acetic acid (5-HIAA) levels and the number of 5-HT uptake sites (determined from (-³H]Paroxetine binding) were significantly decreased in frontal cortex samples at one week killing. A significant decrease in 5-HT and 5-HIAA levels was also observed in rat hippocampal samples. The results provide evidence that β-ethyltryptamine may induce serotonin neurotoxicity similar to that of MDMA and PCA.

Original language	English (US)
Pages (from-to)	187-190
Number of pages	4
Journal	European Journal of Pharmacology
Volume	200
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(91)90686-K
State	Published - Jul 23 1991

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1016/0014-2999(91)90686-K

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title = "Reduction in brain serotonin markers by α-ethyltryptamine (Monase)",

abstract = "α-Ethyltryptamine (Monase) is both an inhibitor of monoamine oxidase and a monoamine releasing agent. To determine whether α-ethyltryptamine induces serotonergic deficits similar to that of other monoamine releasing agents such as 3,4-methyl-enedioxymethamphetamine (MDMA) and para-chloroamphetamine (PCA), rats were given multiple doses (8 × 30 mg/kg s.c.) of α-ethyltryptamine acetate. Serotonin and 5-hydroxyindole acetic acid (5-HIAA) levels and the number of 5-HT uptake sites (determined from (-3H]Paroxetine binding) were significantly decreased in frontal cortex samples at one week killing. A significant decrease in 5-HT and 5-HIAA levels was also observed in rat hippocampal samples. The results provide evidence that β-ethyltryptamine may induce serotonin neurotoxicity similar to that of MDMA and PCA.",

author = "Xuemei Huang and Johnson, {Michael P.} and Nichols, {David E.}",

note = "Funding Information: T&s work was supported hy USPHS",

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T1 - Reduction in brain serotonin markers by α-ethyltryptamine (Monase)

AU - Huang, Xuemei

AU - Johnson, Michael P.

AU - Nichols, David E.

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Y1 - 1991/7/23

N2 - α-Ethyltryptamine (Monase) is both an inhibitor of monoamine oxidase and a monoamine releasing agent. To determine whether α-ethyltryptamine induces serotonergic deficits similar to that of other monoamine releasing agents such as 3,4-methyl-enedioxymethamphetamine (MDMA) and para-chloroamphetamine (PCA), rats were given multiple doses (8 × 30 mg/kg s.c.) of α-ethyltryptamine acetate. Serotonin and 5-hydroxyindole acetic acid (5-HIAA) levels and the number of 5-HT uptake sites (determined from (-3H]Paroxetine binding) were significantly decreased in frontal cortex samples at one week killing. A significant decrease in 5-HT and 5-HIAA levels was also observed in rat hippocampal samples. The results provide evidence that β-ethyltryptamine may induce serotonin neurotoxicity similar to that of MDMA and PCA.

AB - α-Ethyltryptamine (Monase) is both an inhibitor of monoamine oxidase and a monoamine releasing agent. To determine whether α-ethyltryptamine induces serotonergic deficits similar to that of other monoamine releasing agents such as 3,4-methyl-enedioxymethamphetamine (MDMA) and para-chloroamphetamine (PCA), rats were given multiple doses (8 × 30 mg/kg s.c.) of α-ethyltryptamine acetate. Serotonin and 5-hydroxyindole acetic acid (5-HIAA) levels and the number of 5-HT uptake sites (determined from (-3H]Paroxetine binding) were significantly decreased in frontal cortex samples at one week killing. A significant decrease in 5-HT and 5-HIAA levels was also observed in rat hippocampal samples. The results provide evidence that β-ethyltryptamine may induce serotonin neurotoxicity similar to that of MDMA and PCA.

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