Reduction in brain serotonin markers by α-ethyltryptamine (Monase)

Xuemei Huang, Michael P. Johnson, David E. Nichols

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

α-Ethyltryptamine (Monase) is both an inhibitor of monoamine oxidase and a monoamine releasing agent. To determine whether α-ethyltryptamine induces serotonergic deficits similar to that of other monoamine releasing agents such as 3,4-methyl-enedioxymethamphetamine (MDMA) and para-chloroamphetamine (PCA), rats were given multiple doses (8 × 30 mg/kg s.c.) of α-ethyltryptamine acetate. Serotonin and 5-hydroxyindole acetic acid (5-HIAA) levels and the number of 5-HT uptake sites (determined from (-3H]Paroxetine binding) were significantly decreased in frontal cortex samples at one week killing. A significant decrease in 5-HT and 5-HIAA levels was also observed in rat hippocampal samples. The results provide evidence that β-ethyltryptamine may induce serotonin neurotoxicity similar to that of MDMA and PCA.

Original languageEnglish (US)
Pages (from-to)187-190
Number of pages4
JournalEuropean Journal of Pharmacology
Volume200
Issue number1
DOIs
StatePublished - Jul 23 1991

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Serotonin
p-Chloroamphetamine
N-Methyl-3,4-methylenedioxyamphetamine
Brain
Acetic Acid
Paroxetine
Monoamine Oxidase Inhibitors
Frontal Lobe
Acetates
5-hydroxyindole

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Huang, Xuemei ; Johnson, Michael P. ; Nichols, David E. / Reduction in brain serotonin markers by α-ethyltryptamine (Monase). In: European Journal of Pharmacology. 1991 ; Vol. 200, No. 1. pp. 187-190.
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Reduction in brain serotonin markers by α-ethyltryptamine (Monase). / Huang, Xuemei; Johnson, Michael P.; Nichols, David E.

In: European Journal of Pharmacology, Vol. 200, No. 1, 23.07.1991, p. 187-190.

Research output: Contribution to journalArticle

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