Abstract
α-Ethyltryptamine (Monase) is both an inhibitor of monoamine oxidase and a monoamine releasing agent. To determine whether α-ethyltryptamine induces serotonergic deficits similar to that of other monoamine releasing agents such as 3,4-methyl-enedioxymethamphetamine (MDMA) and para-chloroamphetamine (PCA), rats were given multiple doses (8 × 30 mg/kg s.c.) of α-ethyltryptamine acetate. Serotonin and 5-hydroxyindole acetic acid (5-HIAA) levels and the number of 5-HT uptake sites (determined from (-3H]Paroxetine binding) were significantly decreased in frontal cortex samples at one week killing. A significant decrease in 5-HT and 5-HIAA levels was also observed in rat hippocampal samples. The results provide evidence that β-ethyltryptamine may induce serotonin neurotoxicity similar to that of MDMA and PCA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 187-190 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 200 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 23 1991 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
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Reduction in brain serotonin markers by α-ethyltryptamine (Monase). / Huang, Xuemei; Johnson, Michael P.; Nichols, David E.
In: European Journal of Pharmacology, Vol. 200, No. 1, 23.07.1991, p. 187-190.Research output: Contribution to journal › Article
TY - JOUR
T1 - Reduction in brain serotonin markers by α-ethyltryptamine (Monase)
AU - Huang, Xuemei
AU - Johnson, Michael P.
AU - Nichols, David E.
PY - 1991/7/23
Y1 - 1991/7/23
N2 - α-Ethyltryptamine (Monase) is both an inhibitor of monoamine oxidase and a monoamine releasing agent. To determine whether α-ethyltryptamine induces serotonergic deficits similar to that of other monoamine releasing agents such as 3,4-methyl-enedioxymethamphetamine (MDMA) and para-chloroamphetamine (PCA), rats were given multiple doses (8 × 30 mg/kg s.c.) of α-ethyltryptamine acetate. Serotonin and 5-hydroxyindole acetic acid (5-HIAA) levels and the number of 5-HT uptake sites (determined from (-3H]Paroxetine binding) were significantly decreased in frontal cortex samples at one week killing. A significant decrease in 5-HT and 5-HIAA levels was also observed in rat hippocampal samples. The results provide evidence that β-ethyltryptamine may induce serotonin neurotoxicity similar to that of MDMA and PCA.
AB - α-Ethyltryptamine (Monase) is both an inhibitor of monoamine oxidase and a monoamine releasing agent. To determine whether α-ethyltryptamine induces serotonergic deficits similar to that of other monoamine releasing agents such as 3,4-methyl-enedioxymethamphetamine (MDMA) and para-chloroamphetamine (PCA), rats were given multiple doses (8 × 30 mg/kg s.c.) of α-ethyltryptamine acetate. Serotonin and 5-hydroxyindole acetic acid (5-HIAA) levels and the number of 5-HT uptake sites (determined from (-3H]Paroxetine binding) were significantly decreased in frontal cortex samples at one week killing. A significant decrease in 5-HT and 5-HIAA levels was also observed in rat hippocampal samples. The results provide evidence that β-ethyltryptamine may induce serotonin neurotoxicity similar to that of MDMA and PCA.
UR - http://www.scopus.com/inward/record.url?scp=0025778708&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025778708&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(91)90686-K
DO - 10.1016/0014-2999(91)90686-K
M3 - Article
C2 - 1722753
AN - SCOPUS:0025778708
VL - 200
SP - 187
EP - 190
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -