Reduction of perinatal hypoxic-ischemic brain damage with allopurinol

Charles Palmer, Robert C. Vannucci, Javad Towfighi

Research output: Contribution to journalArticlepeer-review

208 Scopus citations

Abstract

Cytotoxic free radicals are generated during cerebral hypoxia-ischemia and reperfusion. We studied the efficacy of allopurinol, a xanthine oxidase inhibitor and free radical scavenger, in reducing posthypoxic-ischemic damage in the developing brain of 7-d-old rat pups. Hypoxic-ischemic injury to the right cerebral hemisphere was produced by ligation of the right common carotid artery followed by 3 h of hypoxia with 8% oxygen. Thirty to 45 min before the hypoxia, the rats received either allopurinol (dose = 130-138 mg/kg) or an equal vol of saline (0.2 mL). Some pups were killed at 42 h of recovery for measurement of cerebral hemispheric water content, whereas others were killed at 30 or more d for neuropathologic examination. A total of 18 allopurinol treated rats had significantly less water content in the right hemisphere (89.07 ± 0.32%) than 23 saline-treated animals (91.64 ± 0.25%, mean ± SEM, p < 0.0001). Rank scoring of neuropathologic alterations revealed that the allopurinol treated rats were less damaged (p = 0.001). Only two of 13 brains from the allopurinol group suffered infarction compared to 10 of the 14 saline-treated animals. The results indicate that allopurinol reduces both cerebral edema and the extent of perinatal hypoxic-ischemic brain damage.

Original languageEnglish (US)
Pages (from-to)332-336
Number of pages5
JournalPediatric Research
Volume27
Issue number4
DOIs
StatePublished - Apr 1990

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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