Reelin binds α3β1 integrin and inhibits neuronal migration

Lori Dulabon, Eric C. Olson, Mary G. Taglienti, Scott Eisenhuth, Barbara Claire McGrath, Christopher A. Walsh, Jordan A. Kreidberg, E. S. Anton

Research output: Contribution to journalArticle

460 Citations (Scopus)

Abstract

Mice that are mutant for Reelin or Dab1, or doubly mutant for the VLDL receptor (VLDLR) and ApoE receptor 2 (ApoER2), show disorders of cerebral cortical lamination. How Reelin and its receptors regulate laminar organization of cerebral cortex is unknown. We show that Reelin inhibits migration of cortical neurons and enables detachment of neurons from radial glia. Recombinant and native Reelin associate with α3β1 integrin, which regulates neuron-glia interactions and is required to achieve proper laminar organization. The effect of Reelin on cortical neuronal migration in vitro and in vivo depends on interactions between Reelin and α3β1 integrin. Absence of α3β1 leads to a reduction of Dab1, a signaling protein acting downstream of Reelin. Thus, Reelin may arrest neuronal migration and promote normal cortical lamination by binding α3β1 integrin and modulating integrin-mediated cellular adhesion.

Original languageEnglish (US)
Pages (from-to)33-44
Number of pages12
JournalNeuron
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2000

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Integrins
Neurons
Neuroglia
Low Density Lipoprotein Receptor-Related Protein-1
Cerebral Cortex
Proteins

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Dulabon, L., Olson, E. C., Taglienti, M. G., Eisenhuth, S., McGrath, B. C., Walsh, C. A., ... Anton, E. S. (2000). Reelin binds α3β1 integrin and inhibits neuronal migration. Neuron, 27(1), 33-44. https://doi.org/10.1016/S0896-6273(00)00007-6
Dulabon, Lori ; Olson, Eric C. ; Taglienti, Mary G. ; Eisenhuth, Scott ; McGrath, Barbara Claire ; Walsh, Christopher A. ; Kreidberg, Jordan A. ; Anton, E. S. / Reelin binds α3β1 integrin and inhibits neuronal migration. In: Neuron. 2000 ; Vol. 27, No. 1. pp. 33-44.
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Dulabon, L, Olson, EC, Taglienti, MG, Eisenhuth, S, McGrath, BC, Walsh, CA, Kreidberg, JA & Anton, ES 2000, 'Reelin binds α3β1 integrin and inhibits neuronal migration', Neuron, vol. 27, no. 1, pp. 33-44. https://doi.org/10.1016/S0896-6273(00)00007-6

Reelin binds α3β1 integrin and inhibits neuronal migration. / Dulabon, Lori; Olson, Eric C.; Taglienti, Mary G.; Eisenhuth, Scott; McGrath, Barbara Claire; Walsh, Christopher A.; Kreidberg, Jordan A.; Anton, E. S.

In: Neuron, Vol. 27, No. 1, 01.01.2000, p. 33-44.

Research output: Contribution to journalArticle

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Dulabon L, Olson EC, Taglienti MG, Eisenhuth S, McGrath BC, Walsh CA et al. Reelin binds α3β1 integrin and inhibits neuronal migration. Neuron. 2000 Jan 1;27(1):33-44. https://doi.org/10.1016/S0896-6273(00)00007-6