Reevaluation of the evolutionary events within recA/RAD51 phylogeny

Sree V. Chintapalli, Gaurav Bhardwaj, Jagadish Babu, Loukia Hadjiyianni, Yoojin Hong, George K. Todd, Casey A. Boosalis, Zhenhai Zhang, Xiaofan Zhou, Hong Ma, Andriy Anishkin, Damian B. van Rossum, Randen L. Patterson

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: The recA/RAD51 gene family encodes a diverse set of recombinase proteins that affect homologous recombination, DNA-repair, and genome stability. The recA gene family is expressed across all three domains of life - Eubacteria, Archaea, and Eukaryotes - and even in some viruses. To date, efforts to resolve the deep evolutionary origins of this ancient protein family have been hindered by the high sequence divergence between paralogous groups (i.e. ~30% average pairwise identity).Results: Through large taxon sampling and the use of a phylogenetic algorithm designed for inferring evolutionary events in highly divergent paralogs, we obtained a robust, parsimonious and more refined phylogenetic history of the recA/RAD51 superfamily.Conclusions: In summary, our model for the evolution of recA/RAD51 family provides a better understanding of the ancient origin of recA proteins and the multiple events that lead to the diversification of recA homologs in eukaryotes, including the discovery of additional RAD51 sub-families.

Original languageEnglish (US)
Article number240
JournalBMC genomics
Volume14
Issue number1
DOIs
StatePublished - Apr 10 2013

Fingerprint

Phylogeny
Eukaryota
Rec A Recombinases
Recombinational DNA Repair
Recombinases
Genomic Instability
Archaea
Genes
Proteins
Viruses
Bacteria

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Genetics

Cite this

Chintapalli, S. V., Bhardwaj, G., Babu, J., Hadjiyianni, L., Hong, Y., Todd, G. K., ... Patterson, R. L. (2013). Reevaluation of the evolutionary events within recA/RAD51 phylogeny. BMC genomics, 14(1), [240]. https://doi.org/10.1186/1471-2164-14-240
Chintapalli, Sree V. ; Bhardwaj, Gaurav ; Babu, Jagadish ; Hadjiyianni, Loukia ; Hong, Yoojin ; Todd, George K. ; Boosalis, Casey A. ; Zhang, Zhenhai ; Zhou, Xiaofan ; Ma, Hong ; Anishkin, Andriy ; van Rossum, Damian B. ; Patterson, Randen L. / Reevaluation of the evolutionary events within recA/RAD51 phylogeny. In: BMC genomics. 2013 ; Vol. 14, No. 1.
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abstract = "Background: The recA/RAD51 gene family encodes a diverse set of recombinase proteins that affect homologous recombination, DNA-repair, and genome stability. The recA gene family is expressed across all three domains of life - Eubacteria, Archaea, and Eukaryotes - and even in some viruses. To date, efforts to resolve the deep evolutionary origins of this ancient protein family have been hindered by the high sequence divergence between paralogous groups (i.e. ~30{\%} average pairwise identity).Results: Through large taxon sampling and the use of a phylogenetic algorithm designed for inferring evolutionary events in highly divergent paralogs, we obtained a robust, parsimonious and more refined phylogenetic history of the recA/RAD51 superfamily.Conclusions: In summary, our model for the evolution of recA/RAD51 family provides a better understanding of the ancient origin of recA proteins and the multiple events that lead to the diversification of recA homologs in eukaryotes, including the discovery of additional RAD51 sub-families.",
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Chintapalli, SV, Bhardwaj, G, Babu, J, Hadjiyianni, L, Hong, Y, Todd, GK, Boosalis, CA, Zhang, Z, Zhou, X, Ma, H, Anishkin, A, van Rossum, DB & Patterson, RL 2013, 'Reevaluation of the evolutionary events within recA/RAD51 phylogeny', BMC genomics, vol. 14, no. 1, 240. https://doi.org/10.1186/1471-2164-14-240

Reevaluation of the evolutionary events within recA/RAD51 phylogeny. / Chintapalli, Sree V.; Bhardwaj, Gaurav; Babu, Jagadish; Hadjiyianni, Loukia; Hong, Yoojin; Todd, George K.; Boosalis, Casey A.; Zhang, Zhenhai; Zhou, Xiaofan; Ma, Hong; Anishkin, Andriy; van Rossum, Damian B.; Patterson, Randen L.

In: BMC genomics, Vol. 14, No. 1, 240, 10.04.2013.

Research output: Contribution to journalArticle

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AU - Bhardwaj, Gaurav

AU - Babu, Jagadish

AU - Hadjiyianni, Loukia

AU - Hong, Yoojin

AU - Todd, George K.

AU - Boosalis, Casey A.

AU - Zhang, Zhenhai

AU - Zhou, Xiaofan

AU - Ma, Hong

AU - Anishkin, Andriy

AU - van Rossum, Damian B.

AU - Patterson, Randen L.

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N2 - Background: The recA/RAD51 gene family encodes a diverse set of recombinase proteins that affect homologous recombination, DNA-repair, and genome stability. The recA gene family is expressed across all three domains of life - Eubacteria, Archaea, and Eukaryotes - and even in some viruses. To date, efforts to resolve the deep evolutionary origins of this ancient protein family have been hindered by the high sequence divergence between paralogous groups (i.e. ~30% average pairwise identity).Results: Through large taxon sampling and the use of a phylogenetic algorithm designed for inferring evolutionary events in highly divergent paralogs, we obtained a robust, parsimonious and more refined phylogenetic history of the recA/RAD51 superfamily.Conclusions: In summary, our model for the evolution of recA/RAD51 family provides a better understanding of the ancient origin of recA proteins and the multiple events that lead to the diversification of recA homologs in eukaryotes, including the discovery of additional RAD51 sub-families.

AB - Background: The recA/RAD51 gene family encodes a diverse set of recombinase proteins that affect homologous recombination, DNA-repair, and genome stability. The recA gene family is expressed across all three domains of life - Eubacteria, Archaea, and Eukaryotes - and even in some viruses. To date, efforts to resolve the deep evolutionary origins of this ancient protein family have been hindered by the high sequence divergence between paralogous groups (i.e. ~30% average pairwise identity).Results: Through large taxon sampling and the use of a phylogenetic algorithm designed for inferring evolutionary events in highly divergent paralogs, we obtained a robust, parsimonious and more refined phylogenetic history of the recA/RAD51 superfamily.Conclusions: In summary, our model for the evolution of recA/RAD51 family provides a better understanding of the ancient origin of recA proteins and the multiple events that lead to the diversification of recA homologs in eukaryotes, including the discovery of additional RAD51 sub-families.

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Chintapalli SV, Bhardwaj G, Babu J, Hadjiyianni L, Hong Y, Todd GK et al. Reevaluation of the evolutionary events within recA/RAD51 phylogeny. BMC genomics. 2013 Apr 10;14(1). 240. https://doi.org/10.1186/1471-2164-14-240