Reference range levels of polycyclic aromatic hydrocarbons in the US population by measurement of urinary monohydroxy metabolites

James Grainger, Wenlin Huang, Donald George Jr Patterson, Wayman E. Turner, James Pirkle, Samuel P. Caudill, Richard Y. Wang, Larry L. Needham, Eric J. Sampson

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

We developed a gas chromatography isotope-dilution high-resolution mass spectrometry (GC/ID-HRMS) method for measuring 14 polycyclic aromatic hydrocarbon (PAH) metabolites representing seven parent PAHs in 3 mL of urine at low parts-per-trillion levels. PAH levels were determined in urine samples collected in 1999 and 2000 from approximately 2400 participants in the National Health and Nutrition Examination Survey, and, for the first time, reference range values were calculated for these metabolites in the US population. Using this GC/ID-HRMS method, we found detectable concentrations for monohydroxy metabolite isomers of fluorene, phenanthrene, fluoranthene, pyrene, and chrysene, benzo[c]phenanthrene, and benz[a]anthracene. Some monohydroxy metabolite isomers of benzo[c]phenanthrene, chrysene, and benz[a]anthracene exhibited low detection frequencies that did not allow for geometric mean calculations. Our study results enabled us to establish a reference range for the targeted PAHs in the general US population.

Original languageEnglish (US)
Pages (from-to)394-423
Number of pages30
JournalEnvironmental Research
Volume100
Issue number3
DOIs
StatePublished - Mar 1 2006

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Polycyclic Aromatic Hydrocarbons
Metabolites
metabolite
PAH
Reference Values
phenanthrene
Isotopes
Gas Chromatography
Mass Spectrometry
Polycyclic aromatic hydrocarbons
Urine
Isomers
Gas chromatography
urine
Population
Dilution
Mass spectrometry
gas chromatography
dilution
mass spectrometry

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Environmental Science(all)

Cite this

Grainger, J., Huang, W., Patterson, D. G. J., Turner, W. E., Pirkle, J., Caudill, S. P., ... Sampson, E. J. (2006). Reference range levels of polycyclic aromatic hydrocarbons in the US population by measurement of urinary monohydroxy metabolites. Environmental Research, 100(3), 394-423. https://doi.org/10.1016/j.envres.2005.06.004
Grainger, James ; Huang, Wenlin ; Patterson, Donald George Jr ; Turner, Wayman E. ; Pirkle, James ; Caudill, Samuel P. ; Wang, Richard Y. ; Needham, Larry L. ; Sampson, Eric J. / Reference range levels of polycyclic aromatic hydrocarbons in the US population by measurement of urinary monohydroxy metabolites. In: Environmental Research. 2006 ; Vol. 100, No. 3. pp. 394-423.
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Grainger, J, Huang, W, Patterson, DGJ, Turner, WE, Pirkle, J, Caudill, SP, Wang, RY, Needham, LL & Sampson, EJ 2006, 'Reference range levels of polycyclic aromatic hydrocarbons in the US population by measurement of urinary monohydroxy metabolites', Environmental Research, vol. 100, no. 3, pp. 394-423. https://doi.org/10.1016/j.envres.2005.06.004

Reference range levels of polycyclic aromatic hydrocarbons in the US population by measurement of urinary monohydroxy metabolites. / Grainger, James; Huang, Wenlin; Patterson, Donald George Jr; Turner, Wayman E.; Pirkle, James; Caudill, Samuel P.; Wang, Richard Y.; Needham, Larry L.; Sampson, Eric J.

In: Environmental Research, Vol. 100, No. 3, 01.03.2006, p. 394-423.

Research output: Contribution to journalArticle

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