Region-specific alteration in brain glutamate: Possible relationship to risk-taking behavior

Bernadette M. Cortese, Todd R. Mitchell, Matthew P. Galloway, Kristen E. Prevost, Jidong Fang, Gregory J. Moore, Thomas W. Uhde

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Risk-taking behaviors involve increased motor activity and reduced anxiety in humans. Total sleep deprivation (SD) in animals produces a similar change in motor and fear behaviors. Investigators studied region-specific brain levels of glutamate in rats after TSD, an animal model of risk-taking behavior. We investigated the effects of sleep deprivation on these behaviors and associated levels of brain glutamate. Compared to the controls, the sleep-deprived rats spent a significantly greater percentage of time in the open arms of the elevated plus maze (EPM), demonstrating reduced fear-like and increased risk-taking behaviors. Additionally, sleep deprivation was associated with a significant increase in glutamate levels in the hippocampus and thalamus. An inverse relationship between glutamate in the medial prefrontal cortex and risk taking in the EPM and a positive association between the ratio of glutamate in the hippocampus to medial prefrontal cortex and risk taking was revealed. The role of sleep deprivation-induced changes in brain glutamate and its relationship to anxiety, fear, and posttraumatic stress disorder (PTSD) is discussed.

Original languageEnglish (US)
Pages (from-to)445-450
Number of pages6
JournalPhysiology and Behavior
Volume99
Issue number4
DOIs
StatePublished - Mar 30 2010

Fingerprint

Risk-Taking
Glutamic Acid
Sleep Deprivation
Brain
Fear
Prefrontal Cortex
Hippocampus
Anxiety
Post-Traumatic Stress Disorders
Thalamus
Sleep
Motor Activity
Animal Models
Research Personnel

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Cortese, B. M., Mitchell, T. R., Galloway, M. P., Prevost, K. E., Fang, J., Moore, G. J., & Uhde, T. W. (2010). Region-specific alteration in brain glutamate: Possible relationship to risk-taking behavior. Physiology and Behavior, 99(4), 445-450. https://doi.org/10.1016/j.physbeh.2009.12.005
Cortese, Bernadette M. ; Mitchell, Todd R. ; Galloway, Matthew P. ; Prevost, Kristen E. ; Fang, Jidong ; Moore, Gregory J. ; Uhde, Thomas W. / Region-specific alteration in brain glutamate : Possible relationship to risk-taking behavior. In: Physiology and Behavior. 2010 ; Vol. 99, No. 4. pp. 445-450.
@article{602f5a9e405042c8bd91c5049ab67a84,
title = "Region-specific alteration in brain glutamate: Possible relationship to risk-taking behavior",
abstract = "Risk-taking behaviors involve increased motor activity and reduced anxiety in humans. Total sleep deprivation (SD) in animals produces a similar change in motor and fear behaviors. Investigators studied region-specific brain levels of glutamate in rats after TSD, an animal model of risk-taking behavior. We investigated the effects of sleep deprivation on these behaviors and associated levels of brain glutamate. Compared to the controls, the sleep-deprived rats spent a significantly greater percentage of time in the open arms of the elevated plus maze (EPM), demonstrating reduced fear-like and increased risk-taking behaviors. Additionally, sleep deprivation was associated with a significant increase in glutamate levels in the hippocampus and thalamus. An inverse relationship between glutamate in the medial prefrontal cortex and risk taking in the EPM and a positive association between the ratio of glutamate in the hippocampus to medial prefrontal cortex and risk taking was revealed. The role of sleep deprivation-induced changes in brain glutamate and its relationship to anxiety, fear, and posttraumatic stress disorder (PTSD) is discussed.",
author = "Cortese, {Bernadette M.} and Mitchell, {Todd R.} and Galloway, {Matthew P.} and Prevost, {Kristen E.} and Jidong Fang and Moore, {Gregory J.} and Uhde, {Thomas W.}",
year = "2010",
month = "3",
day = "30",
doi = "10.1016/j.physbeh.2009.12.005",
language = "English (US)",
volume = "99",
pages = "445--450",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "4",

}

Cortese, BM, Mitchell, TR, Galloway, MP, Prevost, KE, Fang, J, Moore, GJ & Uhde, TW 2010, 'Region-specific alteration in brain glutamate: Possible relationship to risk-taking behavior', Physiology and Behavior, vol. 99, no. 4, pp. 445-450. https://doi.org/10.1016/j.physbeh.2009.12.005

Region-specific alteration in brain glutamate : Possible relationship to risk-taking behavior. / Cortese, Bernadette M.; Mitchell, Todd R.; Galloway, Matthew P.; Prevost, Kristen E.; Fang, Jidong; Moore, Gregory J.; Uhde, Thomas W.

In: Physiology and Behavior, Vol. 99, No. 4, 30.03.2010, p. 445-450.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Region-specific alteration in brain glutamate

T2 - Possible relationship to risk-taking behavior

AU - Cortese, Bernadette M.

AU - Mitchell, Todd R.

AU - Galloway, Matthew P.

AU - Prevost, Kristen E.

AU - Fang, Jidong

AU - Moore, Gregory J.

AU - Uhde, Thomas W.

PY - 2010/3/30

Y1 - 2010/3/30

N2 - Risk-taking behaviors involve increased motor activity and reduced anxiety in humans. Total sleep deprivation (SD) in animals produces a similar change in motor and fear behaviors. Investigators studied region-specific brain levels of glutamate in rats after TSD, an animal model of risk-taking behavior. We investigated the effects of sleep deprivation on these behaviors and associated levels of brain glutamate. Compared to the controls, the sleep-deprived rats spent a significantly greater percentage of time in the open arms of the elevated plus maze (EPM), demonstrating reduced fear-like and increased risk-taking behaviors. Additionally, sleep deprivation was associated with a significant increase in glutamate levels in the hippocampus and thalamus. An inverse relationship between glutamate in the medial prefrontal cortex and risk taking in the EPM and a positive association between the ratio of glutamate in the hippocampus to medial prefrontal cortex and risk taking was revealed. The role of sleep deprivation-induced changes in brain glutamate and its relationship to anxiety, fear, and posttraumatic stress disorder (PTSD) is discussed.

AB - Risk-taking behaviors involve increased motor activity and reduced anxiety in humans. Total sleep deprivation (SD) in animals produces a similar change in motor and fear behaviors. Investigators studied region-specific brain levels of glutamate in rats after TSD, an animal model of risk-taking behavior. We investigated the effects of sleep deprivation on these behaviors and associated levels of brain glutamate. Compared to the controls, the sleep-deprived rats spent a significantly greater percentage of time in the open arms of the elevated plus maze (EPM), demonstrating reduced fear-like and increased risk-taking behaviors. Additionally, sleep deprivation was associated with a significant increase in glutamate levels in the hippocampus and thalamus. An inverse relationship between glutamate in the medial prefrontal cortex and risk taking in the EPM and a positive association between the ratio of glutamate in the hippocampus to medial prefrontal cortex and risk taking was revealed. The role of sleep deprivation-induced changes in brain glutamate and its relationship to anxiety, fear, and posttraumatic stress disorder (PTSD) is discussed.

UR - http://www.scopus.com/inward/record.url?scp=76749171704&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76749171704&partnerID=8YFLogxK

U2 - 10.1016/j.physbeh.2009.12.005

DO - 10.1016/j.physbeh.2009.12.005

M3 - Article

C2 - 20006966

AN - SCOPUS:76749171704

VL - 99

SP - 445

EP - 450

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 4

ER -