Regional and relative adiposity patterns in relation to carbohydrate and lipid metabolism in men with spinal cord injury

Ashraf S. Gorgey, David Gater

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

This study examined the relationship among regional and relative adipose tissue distribution, glucose, and lipid metabolism in men with spinal cord injury (SCI). After overnight fasting, 32 individuals with motor complete tetraplegia (Tetra) (n = 7) and paraplegia (Para) (n = 25) underwent resting energy expenditure and measurement of serum lipid profile, followed by an oral glucose tolerance test to measure plasma glucose and plasma insulin concentrations. Regional fat mass (FM) and fat-free mass were quantified using dual-energy X-ray absorptiometry. Relative adipose tissue was calculated as the ratio of leg FM/trunk FM, leg FM/whole-body FM, and trunk FM/whole-body FM. Individuals with Tetra have greater leg FM/trunk FM (45%) and leg FM/body FM (26%) and lower trunk FM/body FM (29%) ratios than individuals with Para (p < 0.05). Glucose area under the curve (AUC) was positively related to leg FM (r = 0.34, p = 0.05) but not to trunk or body FM. Strong negative relationships were noted between the ratio of trunk FM to body FM and glucose AUC (r = -0.38, p = 0.03) and low-density lipoprotein cholesterol (LDL-C) (r = -0.45, p = 0.001). Whole-body FM was negatively related to high-density lipoprotein cholesterol (r = -0.49, p = 0.007) after controlling for percentage of trunk FM. Both leg and trunk FM may play a pivotal role in determining the metabolic profile in individuals with SCI. Relative to whole-body FM and leg FM, trunk FM may induce a protective effect on glucose homeostasis and the LDL-C profile.

Original languageEnglish (US)
Pages (from-to)107-114
Number of pages8
JournalApplied Physiology, Nutrition and Metabolism
Volume36
Issue number1
DOIs
StatePublished - Feb 1 2011

Fingerprint

Adiposity
Carbohydrate Metabolism
Spinal Cord Injuries
Lipid Metabolism
Fats
Adipose Tissue
Leg
Glucose
Paraplegia
LDL Cholesterol
Area Under Curve
Quadriplegia
Metabolome
Photon Absorptiometry
Tissue Distribution
Glucose Tolerance Test
HDL Cholesterol
Energy Metabolism

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

Cite this

@article{a39164b2c34a4b5391fa50bf9dbf18ba,
title = "Regional and relative adiposity patterns in relation to carbohydrate and lipid metabolism in men with spinal cord injury",
abstract = "This study examined the relationship among regional and relative adipose tissue distribution, glucose, and lipid metabolism in men with spinal cord injury (SCI). After overnight fasting, 32 individuals with motor complete tetraplegia (Tetra) (n = 7) and paraplegia (Para) (n = 25) underwent resting energy expenditure and measurement of serum lipid profile, followed by an oral glucose tolerance test to measure plasma glucose and plasma insulin concentrations. Regional fat mass (FM) and fat-free mass were quantified using dual-energy X-ray absorptiometry. Relative adipose tissue was calculated as the ratio of leg FM/trunk FM, leg FM/whole-body FM, and trunk FM/whole-body FM. Individuals with Tetra have greater leg FM/trunk FM (45{\%}) and leg FM/body FM (26{\%}) and lower trunk FM/body FM (29{\%}) ratios than individuals with Para (p < 0.05). Glucose area under the curve (AUC) was positively related to leg FM (r = 0.34, p = 0.05) but not to trunk or body FM. Strong negative relationships were noted between the ratio of trunk FM to body FM and glucose AUC (r = -0.38, p = 0.03) and low-density lipoprotein cholesterol (LDL-C) (r = -0.45, p = 0.001). Whole-body FM was negatively related to high-density lipoprotein cholesterol (r = -0.49, p = 0.007) after controlling for percentage of trunk FM. Both leg and trunk FM may play a pivotal role in determining the metabolic profile in individuals with SCI. Relative to whole-body FM and leg FM, trunk FM may induce a protective effect on glucose homeostasis and the LDL-C profile.",
author = "Gorgey, {Ashraf S.} and David Gater",
year = "2011",
month = "2",
day = "1",
doi = "10.1139/H10-091",
language = "English (US)",
volume = "36",
pages = "107--114",
journal = "Applied Physiology, Nutrition and Metabolism",
issn = "1715-5312",
publisher = "National Research Council of Canada",
number = "1",

}

Regional and relative adiposity patterns in relation to carbohydrate and lipid metabolism in men with spinal cord injury. / Gorgey, Ashraf S.; Gater, David.

In: Applied Physiology, Nutrition and Metabolism, Vol. 36, No. 1, 01.02.2011, p. 107-114.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Regional and relative adiposity patterns in relation to carbohydrate and lipid metabolism in men with spinal cord injury

AU - Gorgey, Ashraf S.

AU - Gater, David

PY - 2011/2/1

Y1 - 2011/2/1

N2 - This study examined the relationship among regional and relative adipose tissue distribution, glucose, and lipid metabolism in men with spinal cord injury (SCI). After overnight fasting, 32 individuals with motor complete tetraplegia (Tetra) (n = 7) and paraplegia (Para) (n = 25) underwent resting energy expenditure and measurement of serum lipid profile, followed by an oral glucose tolerance test to measure plasma glucose and plasma insulin concentrations. Regional fat mass (FM) and fat-free mass were quantified using dual-energy X-ray absorptiometry. Relative adipose tissue was calculated as the ratio of leg FM/trunk FM, leg FM/whole-body FM, and trunk FM/whole-body FM. Individuals with Tetra have greater leg FM/trunk FM (45%) and leg FM/body FM (26%) and lower trunk FM/body FM (29%) ratios than individuals with Para (p < 0.05). Glucose area under the curve (AUC) was positively related to leg FM (r = 0.34, p = 0.05) but not to trunk or body FM. Strong negative relationships were noted between the ratio of trunk FM to body FM and glucose AUC (r = -0.38, p = 0.03) and low-density lipoprotein cholesterol (LDL-C) (r = -0.45, p = 0.001). Whole-body FM was negatively related to high-density lipoprotein cholesterol (r = -0.49, p = 0.007) after controlling for percentage of trunk FM. Both leg and trunk FM may play a pivotal role in determining the metabolic profile in individuals with SCI. Relative to whole-body FM and leg FM, trunk FM may induce a protective effect on glucose homeostasis and the LDL-C profile.

AB - This study examined the relationship among regional and relative adipose tissue distribution, glucose, and lipid metabolism in men with spinal cord injury (SCI). After overnight fasting, 32 individuals with motor complete tetraplegia (Tetra) (n = 7) and paraplegia (Para) (n = 25) underwent resting energy expenditure and measurement of serum lipid profile, followed by an oral glucose tolerance test to measure plasma glucose and plasma insulin concentrations. Regional fat mass (FM) and fat-free mass were quantified using dual-energy X-ray absorptiometry. Relative adipose tissue was calculated as the ratio of leg FM/trunk FM, leg FM/whole-body FM, and trunk FM/whole-body FM. Individuals with Tetra have greater leg FM/trunk FM (45%) and leg FM/body FM (26%) and lower trunk FM/body FM (29%) ratios than individuals with Para (p < 0.05). Glucose area under the curve (AUC) was positively related to leg FM (r = 0.34, p = 0.05) but not to trunk or body FM. Strong negative relationships were noted between the ratio of trunk FM to body FM and glucose AUC (r = -0.38, p = 0.03) and low-density lipoprotein cholesterol (LDL-C) (r = -0.45, p = 0.001). Whole-body FM was negatively related to high-density lipoprotein cholesterol (r = -0.49, p = 0.007) after controlling for percentage of trunk FM. Both leg and trunk FM may play a pivotal role in determining the metabolic profile in individuals with SCI. Relative to whole-body FM and leg FM, trunk FM may induce a protective effect on glucose homeostasis and the LDL-C profile.

UR - http://www.scopus.com/inward/record.url?scp=79954463861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954463861&partnerID=8YFLogxK

U2 - 10.1139/H10-091

DO - 10.1139/H10-091

M3 - Article

C2 - 21326384

AN - SCOPUS:79954463861

VL - 36

SP - 107

EP - 114

JO - Applied Physiology, Nutrition and Metabolism

JF - Applied Physiology, Nutrition and Metabolism

SN - 1715-5312

IS - 1

ER -