Regional brain cholinesterase activity in rats injected intraperitoneally with anatoxin-a(s) or paraoxon

William O. Cook; John A. Dellinger; Sherene S. Singh; Andrew M. Dahlem; Wayne W. Carmichael; Val Richard Beasley

doi:10.1016/0378-4274(89)90097-0

Regional brain cholinesterase activity in rats injected intraperitoneally with anatoxin-a(s) or paraoxon

William O. Cook, John A. Dellinger, Sherene S. Singh, Andrew M. Dahlem, Wayne W. Carmichael, Val Richard Beasley

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Adult male Long-Evans rats were injected intraperitoneally with 1.5, 3.0 or 9.0 μg/kg of anatoxin-a(s) that had been extracted from laboratory-grown Anabaena flos-aquae NRC-525-17, 800 μg/kg of paraoxon, or a control solution. Blood, anterior spinal cord, and brain cerebellar, cortical, medullary, midbrain, hippocampal, hypothalamic, olfactory and striatal cholinesterase activity was determined in rats that died prior to 2 hours or were anesthetized and killed at 2 hours. Unlike paraoxon, anatoxin-a(s) did not cause detectable inhibition of cholinesterase in the central nervous system, but did cause inhibition of cholinesterase in blood, suggesting that anatoxin-a(s) is strictly a peripheral cholinesterase inhibitor.

Original language	English (US)
Pages (from-to)	29-34
Number of pages	6
Journal	Toxicology Letters
Volume	49
Issue number	1
DOIs	https://doi.org/10.1016/0378-4274(89)90097-0
State	Published - Jan 1 1989

All Science Journal Classification (ASJC) codes

Toxicology

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title = "Regional brain cholinesterase activity in rats injected intraperitoneally with anatoxin-a(s) or paraoxon",

abstract = "Adult male Long-Evans rats were injected intraperitoneally with 1.5, 3.0 or 9.0 μg/kg of anatoxin-a(s) that had been extracted from laboratory-grown Anabaena flos-aquae NRC-525-17, 800 μg/kg of paraoxon, or a control solution. Blood, anterior spinal cord, and brain cerebellar, cortical, medullary, midbrain, hippocampal, hypothalamic, olfactory and striatal cholinesterase activity was determined in rats that died prior to 2 hours or were anesthetized and killed at 2 hours. Unlike paraoxon, anatoxin-a(s) did not cause detectable inhibition of cholinesterase in the central nervous system, but did cause inhibition of cholinesterase in blood, suggesting that anatoxin-a(s) is strictly a peripheral cholinesterase inhibitor.",

author = "Cook, {William O.} and Dellinger, {John A.} and Singh, {Sherene S.} and Dahlem, {Andrew M.} and Carmichael, {Wayne W.} and Beasley, {Val Richard}",

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T1 - Regional brain cholinesterase activity in rats injected intraperitoneally with anatoxin-a(s) or paraoxon

AU - Cook, William O.

AU - Dellinger, John A.

AU - Singh, Sherene S.

AU - Dahlem, Andrew M.

AU - Carmichael, Wayne W.

AU - Beasley, Val Richard

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Adult male Long-Evans rats were injected intraperitoneally with 1.5, 3.0 or 9.0 μg/kg of anatoxin-a(s) that had been extracted from laboratory-grown Anabaena flos-aquae NRC-525-17, 800 μg/kg of paraoxon, or a control solution. Blood, anterior spinal cord, and brain cerebellar, cortical, medullary, midbrain, hippocampal, hypothalamic, olfactory and striatal cholinesterase activity was determined in rats that died prior to 2 hours or were anesthetized and killed at 2 hours. Unlike paraoxon, anatoxin-a(s) did not cause detectable inhibition of cholinesterase in the central nervous system, but did cause inhibition of cholinesterase in blood, suggesting that anatoxin-a(s) is strictly a peripheral cholinesterase inhibitor.

AB - Adult male Long-Evans rats were injected intraperitoneally with 1.5, 3.0 or 9.0 μg/kg of anatoxin-a(s) that had been extracted from laboratory-grown Anabaena flos-aquae NRC-525-17, 800 μg/kg of paraoxon, or a control solution. Blood, anterior spinal cord, and brain cerebellar, cortical, medullary, midbrain, hippocampal, hypothalamic, olfactory and striatal cholinesterase activity was determined in rats that died prior to 2 hours or were anesthetized and killed at 2 hours. Unlike paraoxon, anatoxin-a(s) did not cause detectable inhibition of cholinesterase in the central nervous system, but did cause inhibition of cholinesterase in blood, suggesting that anatoxin-a(s) is strictly a peripheral cholinesterase inhibitor.

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