TY - JOUR
T1 - Regional brain cholinesterase activity in rats injected intraperitoneally with anatoxin-a(s) or paraoxon
AU - Cook, William O.
AU - Dellinger, John A.
AU - Singh, Sherene S.
AU - Dahlem, Andrew M.
AU - Carmichael, Wayne W.
AU - Beasley, Val Richard
PY - 1989/1/1
Y1 - 1989/1/1
N2 - Adult male Long-Evans rats were injected intraperitoneally with 1.5, 3.0 or 9.0 μg/kg of anatoxin-a(s) that had been extracted from laboratory-grown Anabaena flos-aquae NRC-525-17, 800 μg/kg of paraoxon, or a control solution. Blood, anterior spinal cord, and brain cerebellar, cortical, medullary, midbrain, hippocampal, hypothalamic, olfactory and striatal cholinesterase activity was determined in rats that died prior to 2 hours or were anesthetized and killed at 2 hours. Unlike paraoxon, anatoxin-a(s) did not cause detectable inhibition of cholinesterase in the central nervous system, but did cause inhibition of cholinesterase in blood, suggesting that anatoxin-a(s) is strictly a peripheral cholinesterase inhibitor.
AB - Adult male Long-Evans rats were injected intraperitoneally with 1.5, 3.0 or 9.0 μg/kg of anatoxin-a(s) that had been extracted from laboratory-grown Anabaena flos-aquae NRC-525-17, 800 μg/kg of paraoxon, or a control solution. Blood, anterior spinal cord, and brain cerebellar, cortical, medullary, midbrain, hippocampal, hypothalamic, olfactory and striatal cholinesterase activity was determined in rats that died prior to 2 hours or were anesthetized and killed at 2 hours. Unlike paraoxon, anatoxin-a(s) did not cause detectable inhibition of cholinesterase in the central nervous system, but did cause inhibition of cholinesterase in blood, suggesting that anatoxin-a(s) is strictly a peripheral cholinesterase inhibitor.
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U2 - 10.1016/0378-4274(89)90097-0
DO - 10.1016/0378-4274(89)90097-0
M3 - Article
C2 - 2815113
AN - SCOPUS:0024453612
VL - 49
SP - 29
EP - 34
JO - Toxicology Letters
JF - Toxicology Letters
SN - 0378-4274
IS - 1
ER -