Regional brain cholinesterase activity in rats injected intraperitoneally with anatoxin-a(s) or paraoxon

William O. Cook, John A. Dellinger, Sherene S. Singh, Andrew M. Dahlem, Wayne W. Carmichael, Val Richard Beasley

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Abstract

Adult male Long-Evans rats were injected intraperitoneally with 1.5, 3.0 or 9.0 μg/kg of anatoxin-a(s) that had been extracted from laboratory-grown Anabaena flos-aquae NRC-525-17, 800 μg/kg of paraoxon, or a control solution. Blood, anterior spinal cord, and brain cerebellar, cortical, medullary, midbrain, hippocampal, hypothalamic, olfactory and striatal cholinesterase activity was determined in rats that died prior to 2 hours or were anesthetized and killed at 2 hours. Unlike paraoxon, anatoxin-a(s) did not cause detectable inhibition of cholinesterase in the central nervous system, but did cause inhibition of cholinesterase in blood, suggesting that anatoxin-a(s) is strictly a peripheral cholinesterase inhibitor.

Original languageEnglish (US)
Pages (from-to)29-34
Number of pages6
JournalToxicology Letters
Volume49
Issue number1
DOIs
Publication statusPublished - Jan 1 1989

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All Science Journal Classification (ASJC) codes

  • Toxicology

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