Regional cerebral blood flow in normal pressure hydrocephalus

Neill R. Graff-Radford, Karim Rezai, John C. Godersky, Paul Eslinger, Hanna Damasio, Peter T. Kirchner

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Regional cerebral blood flow (rcbf) was studied preoperatively and at 2 and 6 months postoperatively in 22 normal pressure hydrocephalus patients using xenon- 133 inhalation and single photon emission computed tomography. Sixteen of the 22 patients improved (improved group) and six did not (unimproved group). The following comparisons were made: (1) preoperative rcbf in the improved group, to 14 normal elderly volunteers and to that in 59 SDAT (senile dementia of the Alzheimer type) patients; (2) preoperative rcbf in the improved and unimproved groups to determine if rcbf could predict surgical outcome; (3) pre- to postoperative rcbf in the improved group to see if increased cbf accounted for clinical improvement. The findings were: (1) preoperative rcbf in the improved group was lower than that in normal controls but was the same as that in SDAT; however, the ratios of rcbf values in anterior and posterior brain regions were significantly different between improved group and SDAT (p = 002); (2) an anterior/posterior ratio of 105 correctly classified surgical outcome in 19/22 patients; five of six in the unimproved group were above this cut off while 14/16 in the improved group were below; (3) in the improved group rcbf increased at 2 but not at 6 months after surgery without a corresponding reduction of clinical signs, supporting the notion that increase in cbf probably does not account for clinical improvement in normal pressure hydrocephalus.

Original languageEnglish (US)
Pages (from-to)1589-1596
Number of pages8
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume50
Issue number12
DOIs
StatePublished - Jan 1 1987

Fingerprint

Cerebrovascular Circulation
Normal Pressure Hydrocephalus
Regional Blood Flow
Alzheimer Disease
Xenon
Single-Photon Emission-Computed Tomography
Inhalation
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Graff-Radford, N. R., Rezai, K., Godersky, J. C., Eslinger, P., Damasio, H., & Kirchner, P. T. (1987). Regional cerebral blood flow in normal pressure hydrocephalus. Journal of Neurology, Neurosurgery and Psychiatry, 50(12), 1589-1596. https://doi.org/10.1136/jnnp.50.12.1589
Graff-Radford, Neill R. ; Rezai, Karim ; Godersky, John C. ; Eslinger, Paul ; Damasio, Hanna ; Kirchner, Peter T. / Regional cerebral blood flow in normal pressure hydrocephalus. In: Journal of Neurology, Neurosurgery and Psychiatry. 1987 ; Vol. 50, No. 12. pp. 1589-1596.
@article{f7dc8d8ce7bf4f8a91e68db70b715315,
title = "Regional cerebral blood flow in normal pressure hydrocephalus",
abstract = "Regional cerebral blood flow (rcbf) was studied preoperatively and at 2 and 6 months postoperatively in 22 normal pressure hydrocephalus patients using xenon- 133 inhalation and single photon emission computed tomography. Sixteen of the 22 patients improved (improved group) and six did not (unimproved group). The following comparisons were made: (1) preoperative rcbf in the improved group, to 14 normal elderly volunteers and to that in 59 SDAT (senile dementia of the Alzheimer type) patients; (2) preoperative rcbf in the improved and unimproved groups to determine if rcbf could predict surgical outcome; (3) pre- to postoperative rcbf in the improved group to see if increased cbf accounted for clinical improvement. The findings were: (1) preoperative rcbf in the improved group was lower than that in normal controls but was the same as that in SDAT; however, the ratios of rcbf values in anterior and posterior brain regions were significantly different between improved group and SDAT (p = 002); (2) an anterior/posterior ratio of 105 correctly classified surgical outcome in 19/22 patients; five of six in the unimproved group were above this cut off while 14/16 in the improved group were below; (3) in the improved group rcbf increased at 2 but not at 6 months after surgery without a corresponding reduction of clinical signs, supporting the notion that increase in cbf probably does not account for clinical improvement in normal pressure hydrocephalus.",
author = "Graff-Radford, {Neill R.} and Karim Rezai and Godersky, {John C.} and Paul Eslinger and Hanna Damasio and Kirchner, {Peter T.}",
year = "1987",
month = "1",
day = "1",
doi = "10.1136/jnnp.50.12.1589",
language = "English (US)",
volume = "50",
pages = "1589--1596",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "12",

}

Graff-Radford, NR, Rezai, K, Godersky, JC, Eslinger, P, Damasio, H & Kirchner, PT 1987, 'Regional cerebral blood flow in normal pressure hydrocephalus', Journal of Neurology, Neurosurgery and Psychiatry, vol. 50, no. 12, pp. 1589-1596. https://doi.org/10.1136/jnnp.50.12.1589

Regional cerebral blood flow in normal pressure hydrocephalus. / Graff-Radford, Neill R.; Rezai, Karim; Godersky, John C.; Eslinger, Paul; Damasio, Hanna; Kirchner, Peter T.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 50, No. 12, 01.01.1987, p. 1589-1596.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Regional cerebral blood flow in normal pressure hydrocephalus

AU - Graff-Radford, Neill R.

AU - Rezai, Karim

AU - Godersky, John C.

AU - Eslinger, Paul

AU - Damasio, Hanna

AU - Kirchner, Peter T.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Regional cerebral blood flow (rcbf) was studied preoperatively and at 2 and 6 months postoperatively in 22 normal pressure hydrocephalus patients using xenon- 133 inhalation and single photon emission computed tomography. Sixteen of the 22 patients improved (improved group) and six did not (unimproved group). The following comparisons were made: (1) preoperative rcbf in the improved group, to 14 normal elderly volunteers and to that in 59 SDAT (senile dementia of the Alzheimer type) patients; (2) preoperative rcbf in the improved and unimproved groups to determine if rcbf could predict surgical outcome; (3) pre- to postoperative rcbf in the improved group to see if increased cbf accounted for clinical improvement. The findings were: (1) preoperative rcbf in the improved group was lower than that in normal controls but was the same as that in SDAT; however, the ratios of rcbf values in anterior and posterior brain regions were significantly different between improved group and SDAT (p = 002); (2) an anterior/posterior ratio of 105 correctly classified surgical outcome in 19/22 patients; five of six in the unimproved group were above this cut off while 14/16 in the improved group were below; (3) in the improved group rcbf increased at 2 but not at 6 months after surgery without a corresponding reduction of clinical signs, supporting the notion that increase in cbf probably does not account for clinical improvement in normal pressure hydrocephalus.

AB - Regional cerebral blood flow (rcbf) was studied preoperatively and at 2 and 6 months postoperatively in 22 normal pressure hydrocephalus patients using xenon- 133 inhalation and single photon emission computed tomography. Sixteen of the 22 patients improved (improved group) and six did not (unimproved group). The following comparisons were made: (1) preoperative rcbf in the improved group, to 14 normal elderly volunteers and to that in 59 SDAT (senile dementia of the Alzheimer type) patients; (2) preoperative rcbf in the improved and unimproved groups to determine if rcbf could predict surgical outcome; (3) pre- to postoperative rcbf in the improved group to see if increased cbf accounted for clinical improvement. The findings were: (1) preoperative rcbf in the improved group was lower than that in normal controls but was the same as that in SDAT; however, the ratios of rcbf values in anterior and posterior brain regions were significantly different between improved group and SDAT (p = 002); (2) an anterior/posterior ratio of 105 correctly classified surgical outcome in 19/22 patients; five of six in the unimproved group were above this cut off while 14/16 in the improved group were below; (3) in the improved group rcbf increased at 2 but not at 6 months after surgery without a corresponding reduction of clinical signs, supporting the notion that increase in cbf probably does not account for clinical improvement in normal pressure hydrocephalus.

UR - http://www.scopus.com/inward/record.url?scp=0023613713&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023613713&partnerID=8YFLogxK

U2 - 10.1136/jnnp.50.12.1589

DO - 10.1136/jnnp.50.12.1589

M3 - Article

VL - 50

SP - 1589

EP - 1596

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 12

ER -