Regional distribution of cardiac output in conscious rats at rest and during exercise. Effects of diltiazem

S. F. Flaim, R. F. Zelis

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The effects of intravenous infusion of the calcium antagonist, diltiazem (6, 30, and 150 mg/kg/hr) on cardiac and circulatory hemodynamics and on regional blood flow and cardiac output distribution to the major peripheral circulations were studied in conscious, normal Sprague-Dawley rats in the resting state. Therapy with diltiazem consistently increased cardiac output levels, as well as stroke volume, and decreased mean arterial pressure and systemic vascular resistance in a dose-related fashion. Diltiazem had a substantial effect on increasing coronary blood flow and reducing coronary vascular resistance. Effects of similar direction and magnitude were observed in the cerebral and hepatic arterial circulations. In a second study, rats were subjected to a submaximal treadmill exercise protocol during continuous intravenous infusion of either saline solution or diltiazem (DZ) in order to determine the effects of this agent on cardiac output distribution during exercise. The results indicate that the positive effects of diltiazem on cardiac output are maintained during exercise. The increase in cardiac output with diltiazem appears to be distributed throughout the major regional circulations in proportion to regional demand.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalCHEST
Volume78
Issue number1 SUPPL.
DOIs
StatePublished - Jan 1 1980

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Regional distribution of cardiac output in conscious rats at rest and during exercise. Effects of diltiazem'. Together they form a unique fingerprint.

  • Cite this