Abstract

Objective: To demonstrate whether the regional recurrence (RR) of squamous cell carcinoma (SCC) of the nasal cavity is higher than previously suspected. Data Sources: Original articles, including a previously published series from our institution, were identified from systematic searches of the MEDLINE database. Study Selection: Studies that analyzed tumors other than SCC or tumors from sites other than the nasal cavity were excluded. Studies that did not report an RR were also excluded. Data Extraction: Studies identified by the literature search were reviewed by a single reviewer (W.C.S.), and studies not excluded were reviewed for data extraction by 2 reviewers (W.C.S. and M.Y.C.). Data Synthesis: From the 23 studies reviewed, the average weighted percentage RR for SCC of the nasal cavity was 18.1% (95% confidence interval, 13.4%-22.8%). Conclusions: Currently, few authors advocate elective treatment of the neck in patients with high-risk SCC of the nasal cavity. The results of this systematic review and meta-analysis demonstrate that the RR of this entity may be higher than previously suspected. Because many studies included other histopathologies or analyzed recurrence data from tumors of multiple subsites, a true RR for SCC of the nasal cavity has not been firmly established. Now that a uniform staging system exists for nasal cavity cancers, better prospective analysis of these tumors will be available. The authors suggest that the risk of RR of certain high-risk SCCs of the nasal cavity to the lymph nodes, including the perifacial and upper cervical lymphatics, may approach the frequently cited 20% risk suggestive of consideration for elective regional therapy.

Original languageEnglish (US)
Pages (from-to)796-800
Number of pages5
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume133
Issue number8
DOIs
StatePublished - Aug 1 2007

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Nasal Cavity
Meta-Analysis
Squamous Cell Carcinoma
Recurrence
Neoplasms
Nose Neoplasms
Information Storage and Retrieval
MEDLINE
Neck
Lymph Nodes
Databases
Confidence Intervals
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology

Cite this

@article{7ca56750b7b24bd8a8110651a70de509,
title = "Regional recurrence of squamous cell carcinoma of the nasal cavity: A systematic review and meta-analysis",
abstract = "Objective: To demonstrate whether the regional recurrence (RR) of squamous cell carcinoma (SCC) of the nasal cavity is higher than previously suspected. Data Sources: Original articles, including a previously published series from our institution, were identified from systematic searches of the MEDLINE database. Study Selection: Studies that analyzed tumors other than SCC or tumors from sites other than the nasal cavity were excluded. Studies that did not report an RR were also excluded. Data Extraction: Studies identified by the literature search were reviewed by a single reviewer (W.C.S.), and studies not excluded were reviewed for data extraction by 2 reviewers (W.C.S. and M.Y.C.). Data Synthesis: From the 23 studies reviewed, the average weighted percentage RR for SCC of the nasal cavity was 18.1{\%} (95{\%} confidence interval, 13.4{\%}-22.8{\%}). Conclusions: Currently, few authors advocate elective treatment of the neck in patients with high-risk SCC of the nasal cavity. The results of this systematic review and meta-analysis demonstrate that the RR of this entity may be higher than previously suspected. Because many studies included other histopathologies or analyzed recurrence data from tumors of multiple subsites, a true RR for SCC of the nasal cavity has not been firmly established. Now that a uniform staging system exists for nasal cavity cancers, better prospective analysis of these tumors will be available. The authors suggest that the risk of RR of certain high-risk SCCs of the nasal cavity to the lymph nodes, including the perifacial and upper cervical lymphatics, may approach the frequently cited 20{\%} risk suggestive of consideration for elective regional therapy.",
author = "Scurry, {W. Cooper} and David Goldenberg and Chee, {Michael Y.} and Lengerich, {Eugene J.} and Yihai Liu and Fedok, {Fred G.}",
year = "2007",
month = "8",
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doi = "10.1001/archotol.133.8.796",
language = "English (US)",
volume = "133",
pages = "796--800",
journal = "JAMA Otolaryngology - Head and Neck Surgery",
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}

Regional recurrence of squamous cell carcinoma of the nasal cavity : A systematic review and meta-analysis. / Scurry, W. Cooper; Goldenberg, David; Chee, Michael Y.; Lengerich, Eugene J.; Liu, Yihai; Fedok, Fred G.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 133, No. 8, 01.08.2007, p. 796-800.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Regional recurrence of squamous cell carcinoma of the nasal cavity

T2 - A systematic review and meta-analysis

AU - Scurry, W. Cooper

AU - Goldenberg, David

AU - Chee, Michael Y.

AU - Lengerich, Eugene J.

AU - Liu, Yihai

AU - Fedok, Fred G.

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Objective: To demonstrate whether the regional recurrence (RR) of squamous cell carcinoma (SCC) of the nasal cavity is higher than previously suspected. Data Sources: Original articles, including a previously published series from our institution, were identified from systematic searches of the MEDLINE database. Study Selection: Studies that analyzed tumors other than SCC or tumors from sites other than the nasal cavity were excluded. Studies that did not report an RR were also excluded. Data Extraction: Studies identified by the literature search were reviewed by a single reviewer (W.C.S.), and studies not excluded were reviewed for data extraction by 2 reviewers (W.C.S. and M.Y.C.). Data Synthesis: From the 23 studies reviewed, the average weighted percentage RR for SCC of the nasal cavity was 18.1% (95% confidence interval, 13.4%-22.8%). Conclusions: Currently, few authors advocate elective treatment of the neck in patients with high-risk SCC of the nasal cavity. The results of this systematic review and meta-analysis demonstrate that the RR of this entity may be higher than previously suspected. Because many studies included other histopathologies or analyzed recurrence data from tumors of multiple subsites, a true RR for SCC of the nasal cavity has not been firmly established. Now that a uniform staging system exists for nasal cavity cancers, better prospective analysis of these tumors will be available. The authors suggest that the risk of RR of certain high-risk SCCs of the nasal cavity to the lymph nodes, including the perifacial and upper cervical lymphatics, may approach the frequently cited 20% risk suggestive of consideration for elective regional therapy.

AB - Objective: To demonstrate whether the regional recurrence (RR) of squamous cell carcinoma (SCC) of the nasal cavity is higher than previously suspected. Data Sources: Original articles, including a previously published series from our institution, were identified from systematic searches of the MEDLINE database. Study Selection: Studies that analyzed tumors other than SCC or tumors from sites other than the nasal cavity were excluded. Studies that did not report an RR were also excluded. Data Extraction: Studies identified by the literature search were reviewed by a single reviewer (W.C.S.), and studies not excluded were reviewed for data extraction by 2 reviewers (W.C.S. and M.Y.C.). Data Synthesis: From the 23 studies reviewed, the average weighted percentage RR for SCC of the nasal cavity was 18.1% (95% confidence interval, 13.4%-22.8%). Conclusions: Currently, few authors advocate elective treatment of the neck in patients with high-risk SCC of the nasal cavity. The results of this systematic review and meta-analysis demonstrate that the RR of this entity may be higher than previously suspected. Because many studies included other histopathologies or analyzed recurrence data from tumors of multiple subsites, a true RR for SCC of the nasal cavity has not been firmly established. Now that a uniform staging system exists for nasal cavity cancers, better prospective analysis of these tumors will be available. The authors suggest that the risk of RR of certain high-risk SCCs of the nasal cavity to the lymph nodes, including the perifacial and upper cervical lymphatics, may approach the frequently cited 20% risk suggestive of consideration for elective regional therapy.

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