Regional vascular adjustments during recovery from myocardial infarction in rats

Helmut Drexler, Edward J. Toggart, Mark R. Glick, Jim Heald, Stephen F. Flaim, Robert Zelis

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Abstract

Left ventricular function and systemic regional blood flow (radioactive microspheres, 15 ± 5 μ) were studied 1, 3, 10 or 42 days after left coronary occlusion in conscious rats. One day after coronary occlusion, vascular resistance in the skeletal muscle and cutaneous beds increased while stroke work and left ventricular systolic pressure were depressed. Regional blood flow and hemodynamic data were similar for sham and infarction groups at 3 and 10 days after surgery, except for left ventricular end-diastolic pressure, which was significantly increased in rats with infarction (sham versus infarct: 11.5 ± 1.0 versus 18.4 ± 3.2 at day 3 and 12.2 ± 1.4 versus 19.9 ± 3.2 at day 10) (p < 0.05). At 42 days after myocardial infarction, manifest heart failure occurred as documented by decreased cardiac output and left ventricular systolic pressure and elevated left ventricular end-diastolic pressure and vascular resistance in the cutaneous, skeletal muscle and renal beds. In a separate group of animals with moderate (33.2 ±2% of left ventricle) and large infarctions (45 ±1.3% of left ventricle), regional blood flow was compared with the sham group. Rats with a large infarct demonstrated significant (p < 0.05) reduction in flow to kidney, gut and liver. In rats with a medium sized infarct, only renal blood flow was significantly reduced. It is concluded that in this model of myocardial infarction, early cardiocirculatory depression is followed by a partially compensated state with increased left ventricular end-diastolic pressure and subsequent systemic and regional vasoconstriction which, in turn, may contribute to late deterioration of heart failure.

Original languageEnglish (US)
Pages (from-to)134-142
Number of pages9
JournalJournal of the American College of Cardiology
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 1 1986

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All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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