A direct procedure for regioselective α-monochlorination of various N-sulfonyl and N-acyl-protected-3-piperidones with N-chlorosuccinimide (NCS) and Amberlyst-15 ion exchange resin is reported which leads predominantly (or exclusively) to 4-chloro-3-piperidones in all cases.
|Original language||English (US)|
|Number of pages||9|
|State||Published - Dec 22 2011|
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Organic Chemistry