Regioselective α-Monochlorination of N-protected-3-piperidones

Pradeep S. Chauhan, Max M. Majireck, Steven M. Weinreb

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A direct procedure for regioselective α-monochlorination of various N-sulfonyl and N-acyl-protected-3-piperidones with N-chlorosuccinimide (NCS) and Amberlyst-15 ion exchange resin is reported which leads predominantly (or exclusively) to 4-chloro-3-piperidones in all cases.

Original languageEnglish (US)
Pages (from-to)577-585
Number of pages9
JournalHeterocycles
Volume84
Issue number1
DOIs
StatePublished - Dec 22 2011

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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    Chauhan, P. S., Majireck, M. M., & Weinreb, S. M. (2011). Regioselective α-Monochlorination of N-protected-3-piperidones. Heterocycles, 84(1), 577-585. https://doi.org/10.3987/COM-11-S(P)23