Regulated expression of calmodulin-dependent cyclic nucleotide phosphodiesterase in the central nervous system

R. L. Kincaid, C. D. Balaban, Melvin Billingsley

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Recently we carried out immunocytochemical studies in rat brain, documenting the distribution of phosphodiesterase, and comparing the localization of this enzyme with that of the CaM-regulated phosphoprotein phosphatase, calcineurin, which also is highly concentrated in CNS tissue. Our data suggest strongly that expression of phosphodiesterase is highly controlled in the central nervous system, in apparent contrast to that seen for calcineurin. Preliminary evidence indicates that the striking specificity seen in the normal adult brain may arise from neuronal differentiation that occurs during early postnatal development. Perhaps most exciting is the recent finding that selective down-regulation of expression in adult tissue occurs after disruption of specific synaptic inputs, suggesting that transsynaptic influences participate in the regulation of the phosphodiesterase gene.

Original languageEnglish (US)
Pages (from-to)473-486
Number of pages14
JournalJournal of Cyclic Nucleotide and Protein Phosphorylation Research
Volume11
Issue number7
StatePublished - Dec 1 1986

All Science Journal Classification (ASJC) codes

  • Biochemistry

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