Recently we carried out immunocytochemical studies in rat brain, documenting the distribution of phosphodiesterase, and comparing the localization of this enzyme with that of the CaM-regulated phosphoprotein phosphatase, calcineurin, which also is highly concentrated in CNS tissue. Our data suggest strongly that expression of phosphodiesterase is highly controlled in the central nervous system, in apparent contrast to that seen for calcineurin. Preliminary evidence indicates that the striking specificity seen in the normal adult brain may arise from neuronal differentiation that occurs during early postnatal development. Perhaps most exciting is the recent finding that selective down-regulation of expression in adult tissue occurs after disruption of specific synaptic inputs, suggesting that transsynaptic influences participate in the regulation of the phosphodiesterase gene.
|Original language||English (US)|
|Number of pages||14|
|Journal||Journal of Cyclic Nucleotide and Protein Phosphorylation Research|
|State||Published - Dec 1 1986|
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