Regulated import and degradation of a cytosolic protein in the yeast vacuole

Hui Ling Chiang, Randy Schekman

Research output: Contribution to journalArticlepeer-review

126 Scopus citations

Abstract

The key regulatory enzyme in gluconeogenesis, fructose 1,6-bisphosphatase (FBPase) is subject to glucose-stimulated proteolytic degradation in Saccharomyces cerevisiae. This process involves the regulated transfer of FBPase directly from the cytosol into the vacuole or a vacuole-related organelle. Glucose may regulate the production of an FBPase receptor or import factor that is transported to the vacuole through the secretory pathway.

Original languageEnglish (US)
Pages (from-to)313-318
Number of pages6
JournalNature
Volume350
Issue number6316
DOIs
StatePublished - Jan 1 1991

All Science Journal Classification (ASJC) codes

  • General

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