Regulating life or death: Potential role of microRNA in rescue of the corpus luteum

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The role of miRNA in tissue biology has added a new level of understanding of gene regulation and function. The corpus luteum (CL) is a transitory endocrine gland; the dynamic nature of the CL makes it a candidate for regulation by miRNA. Rescue of the CL from luteolysis is essential for the maintenance of pregnancy in all eutherian mammals. Using next generation sequencing, we profiled miRNA expression in the bovine CL during maternal recognition of pregnancy. We identified 590 luteal miRNA, of which 544 were known and 46 were novel miRNAs. Fifteen (including 3 novel) miRNAs were differentially expressed between CL of pregnant vs. cyclic animals. Target analysis of the differentially expressed miRNA resulted in genes involved in regulating apoptosis and immune response, providing evidence that miRNAs regulate the intracellular pathways that lead to either luteal regression or survival.

Original languageEnglish (US)
Pages (from-to)78-88
Number of pages11
JournalMolecular and Cellular Endocrinology
Volume398
Issue number1-2
DOIs
StatePublished - Dec 1 2014

Fingerprint

Corpus Luteum
MicroRNAs
Luteolysis
Pregnancy Maintenance
Endocrine Glands
Mammals
Gene expression
Genes
Animals
Mothers
Tissue
Apoptosis
Pregnancy

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

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abstract = "The role of miRNA in tissue biology has added a new level of understanding of gene regulation and function. The corpus luteum (CL) is a transitory endocrine gland; the dynamic nature of the CL makes it a candidate for regulation by miRNA. Rescue of the CL from luteolysis is essential for the maintenance of pregnancy in all eutherian mammals. Using next generation sequencing, we profiled miRNA expression in the bovine CL during maternal recognition of pregnancy. We identified 590 luteal miRNA, of which 544 were known and 46 were novel miRNAs. Fifteen (including 3 novel) miRNAs were differentially expressed between CL of pregnant vs. cyclic animals. Target analysis of the differentially expressed miRNA resulted in genes involved in regulating apoptosis and immune response, providing evidence that miRNAs regulate the intracellular pathways that lead to either luteal regression or survival.",
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Regulating life or death : Potential role of microRNA in rescue of the corpus luteum. / Maalouf, Samar W.; Liu, Wansheng; Albert, Istvan; Pate, Joy Lee.

In: Molecular and Cellular Endocrinology, Vol. 398, No. 1-2, 01.12.2014, p. 78-88.

Research output: Contribution to journalArticle

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