Regulation of antiviral CD8+ T cells by inhibitory natural killer cell receptors

Anthony M. Byers; Christopher C. Kemball; Nicolas P. Andrews; Aron E. Lukacher

doi:10.1016/S1286-4579(02)00086-2

Regulation of antiviral CD8⁺ T cells by inhibitory natural killer cell receptors

Anthony M. Byers, Christopher C. Kemball, Nicolas P. Andrews, Aron E. Lukacher

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Recent evidence indicates that CD8⁺ T cells express natural killer cell receptors that constrain the range and magnitude of their activities. For virus-specific CD8⁺ T cells, upregulation of these receptors serves to control infection, while concurrently minimizing bystander pathology. Dysregulated expression of these receptors, however, may foster the establishment of persistent virus infection.

Original language	English (US)
Pages (from-to)	169-177
Number of pages	9
Journal	Microbes and Infection
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/S1286-4579(02)00086-2
State	Published - Feb 1 2003

All Science Journal Classification (ASJC) codes

Microbiology
Immunology
Infectious Diseases

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10.1016/S1286-4579(02)00086-2

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abstract = "Recent evidence indicates that CD8+ T cells express natural killer cell receptors that constrain the range and magnitude of their activities. For virus-specific CD8+ T cells, upregulation of these receptors serves to control infection, while concurrently minimizing bystander pathology. Dysregulated expression of these receptors, however, may foster the establishment of persistent virus infection.",

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AB - Recent evidence indicates that CD8+ T cells express natural killer cell receptors that constrain the range and magnitude of their activities. For virus-specific CD8+ T cells, upregulation of these receptors serves to control infection, while concurrently minimizing bystander pathology. Dysregulated expression of these receptors, however, may foster the establishment of persistent virus infection.

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