Regulation of Glucose Transporter and Hormone Receptor Cycling by Insulin in the Rat Adipose Cell

Ian Simpson, Samuel W. Cushman

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This chapter discusses the regulation of glucose transporter and hormone receptor cycling by insulin in the rat adipose cell. The direct measurement of glucose uptake into rat adipose cells is clearly complicated by the cell's ability to rapidly metabolize this transport substrate. This problem has been overcome by using nonmetabolizable glucose analogs—such as L-arabinose, L-xylose, 2-deoxyglucose, and 3-O-methylglucose—of which the latter is now considered the analog of choice. In almost the entire cell types so far investigated, insulin has been shown to be internalized and degraded through receptor-mediated endocytosis. Unlike many cell types, chronic exposure of the rat adipose cell to insulin results in very little apparent loss of cell surface insulin receptors-so-called “down-regulation.” The rapidity with which the insulin receptor is internalized in the rat adipose cell parallels the stimulation of both glucose transport and the redistribution of IGF-II receptors by insulin. The rapidity with which the insulin receptor is internalized in the rat adipose cell parallels the stimulation of both glucose transport and the redistribution of IGF-II receptors by insulin.

Original languageEnglish (US)
Pages (from-to)459-503
Number of pages45
JournalCurrent Topics in Membranes and Transport
Volume24
Issue numberC
DOIs
StatePublished - Jan 1 1985

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Facilitative Glucose Transport Proteins
Insulin Receptor
Hormones
Insulin
IGF Type 2 Receptor
Glucose
Arabinose
Xylose
Deoxyglucose
Cell Surface Receptors
Endocytosis
Down-Regulation

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

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Regulation of Glucose Transporter and Hormone Receptor Cycling by Insulin in the Rat Adipose Cell. / Simpson, Ian; Cushman, Samuel W.

In: Current Topics in Membranes and Transport, Vol. 24, No. C, 01.01.1985, p. 459-503.

Research output: Contribution to journalArticle

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