Regulation of mycobacterial growth by the hypothalamus-pituitary-adrenal axis

Differential responses of Mycobacterium bovis BCG-resistant and - susceptible mice

D. H. Brown, J. Sheridan, Dennis Keith Pearl, B. S. Zwilling

Research output: Contribution to journalArticle

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Abstract

The role of the hypothalamus-pituitary-adrenal (HPA) axis in regulating the growth of Mycobacterium avium in Mycobacterium bovis BCG-resistant and - susceptible congenic mice was evaluated. Restraint was used to activate the HPA axis, which resulted in an increase in the level of corticosterone in the plasma. Activation of the HPA axis increased the susceptibility of BALB/c.Bcg(s) mice to the growth of M. avium. In contrast, the growth of M. avium was not altered in BALB/c.Bcg(r) mice as a result of HPA activation. Adrenalectomy abolished the effect of HPA activation on mycobacterial growth, as did treatment of the mice with a glucocorticoid receptor antagonist, RU 486. Activation of the HPA axis also resulted in the increased susceptibility of splenic macrophages from Bcg(s) mice but not from Bcg(r) mice to M. avium growth in vitro. The production of tumor necrosis factor alpha and of reactive nitrogen intermediates by splenic macrophages from both strains of mice was suppressed as a result of HPA activation. The implications of these findings for resistance controlled by Bcg and for susceptibility to mycobacterial growth are discussed.

Original languageEnglish (US)
Pages (from-to)4793-4800
Number of pages8
JournalInfection and Immunity
Volume61
Issue number11
StatePublished - 1993

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Mycobacterium bovis
Hypothalamus
Mycobacterium avium
Growth
Macrophages
Congenic Mice
Mifepristone
Adrenalectomy
Glucocorticoid Receptors
Corticosterone
Nitrogen
Tumor Necrosis Factor-alpha

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

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abstract = "The role of the hypothalamus-pituitary-adrenal (HPA) axis in regulating the growth of Mycobacterium avium in Mycobacterium bovis BCG-resistant and - susceptible congenic mice was evaluated. Restraint was used to activate the HPA axis, which resulted in an increase in the level of corticosterone in the plasma. Activation of the HPA axis increased the susceptibility of BALB/c.Bcg(s) mice to the growth of M. avium. In contrast, the growth of M. avium was not altered in BALB/c.Bcg(r) mice as a result of HPA activation. Adrenalectomy abolished the effect of HPA activation on mycobacterial growth, as did treatment of the mice with a glucocorticoid receptor antagonist, RU 486. Activation of the HPA axis also resulted in the increased susceptibility of splenic macrophages from Bcg(s) mice but not from Bcg(r) mice to M. avium growth in vitro. The production of tumor necrosis factor alpha and of reactive nitrogen intermediates by splenic macrophages from both strains of mice was suppressed as a result of HPA activation. The implications of these findings for resistance controlled by Bcg and for susceptibility to mycobacterial growth are discussed.",
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Regulation of mycobacterial growth by the hypothalamus-pituitary-adrenal axis : Differential responses of Mycobacterium bovis BCG-resistant and - susceptible mice. / Brown, D. H.; Sheridan, J.; Pearl, Dennis Keith; Zwilling, B. S.

In: Infection and Immunity, Vol. 61, No. 11, 1993, p. 4793-4800.

Research output: Contribution to journalArticle

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