Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin, amino acid- and exercise-induced signalling

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Although insulin, amino acids and exercise individually activate multiple signal transduction pathways in skeletal muscle, one pathway, the phosphatidylinositol 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) signalling pathway, is a target of all three. Activation of the PI3K-mTOR signal transduction pathway results in both acute (i.e. occurring in minutes to hours) and long-term (i.e. occurring in hours to days) up-regulation of protein synthesis through modulation of multiple steps involved in mediating the initiation of mRNA translation and ribosome biogenesis respectively. In addition, changes in gene expression through altered patterns of mRNA translation promote cell growth, which in turn promotes muscle hypertrophy. The focus of the present discussion is to review current knowledge concerning the mechanism(s) through which insulin, amino acids and resistance exercise act to activate the PI3K-mTOR signal transduction pathway and thereby enhance the rate of protein synthesis in muscle.

Original languageEnglish (US)
Pages (from-to)351-356
Number of pages6
JournalProceedings of the Nutrition Society
Volume63
Issue number2
DOIs
StatePublished - May 1 2004

Fingerprint

Phosphatidylinositol 3-Kinase
phosphatidylinositol 3-kinase
Sirolimus
hypertrophy
Hypertrophy
skeletal muscle
signal transduction
Signal Transduction
Skeletal Muscle
exercise
insulin
protein synthesis
Protein Biosynthesis
Insulin
Amino Acids
translation (genetics)
amino acids
strength training
Muscles
muscles

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

@article{4d7e8af5d6ca4e39a7f3682aaf28b396,
title = "Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin, amino acid- and exercise-induced signalling",
abstract = "Although insulin, amino acids and exercise individually activate multiple signal transduction pathways in skeletal muscle, one pathway, the phosphatidylinositol 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) signalling pathway, is a target of all three. Activation of the PI3K-mTOR signal transduction pathway results in both acute (i.e. occurring in minutes to hours) and long-term (i.e. occurring in hours to days) up-regulation of protein synthesis through modulation of multiple steps involved in mediating the initiation of mRNA translation and ribosome biogenesis respectively. In addition, changes in gene expression through altered patterns of mRNA translation promote cell growth, which in turn promotes muscle hypertrophy. The focus of the present discussion is to review current knowledge concerning the mechanism(s) through which insulin, amino acids and resistance exercise act to activate the PI3K-mTOR signal transduction pathway and thereby enhance the rate of protein synthesis in muscle.",
author = "Bolster, {Douglas R.} and Jefferson, {Leonard S.} and Kimball, {Scot R.}",
year = "2004",
month = "5",
day = "1",
doi = "10.1079/PNS2004355",
language = "English (US)",
volume = "63",
pages = "351--356",
journal = "Proceedings of the Nutrition Society",
issn = "0029-6651",
publisher = "Cambridge University Press",
number = "2",

}

TY - JOUR

T1 - Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin, amino acid- and exercise-induced signalling

AU - Bolster, Douglas R.

AU - Jefferson, Leonard S.

AU - Kimball, Scot R.

PY - 2004/5/1

Y1 - 2004/5/1

N2 - Although insulin, amino acids and exercise individually activate multiple signal transduction pathways in skeletal muscle, one pathway, the phosphatidylinositol 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) signalling pathway, is a target of all three. Activation of the PI3K-mTOR signal transduction pathway results in both acute (i.e. occurring in minutes to hours) and long-term (i.e. occurring in hours to days) up-regulation of protein synthesis through modulation of multiple steps involved in mediating the initiation of mRNA translation and ribosome biogenesis respectively. In addition, changes in gene expression through altered patterns of mRNA translation promote cell growth, which in turn promotes muscle hypertrophy. The focus of the present discussion is to review current knowledge concerning the mechanism(s) through which insulin, amino acids and resistance exercise act to activate the PI3K-mTOR signal transduction pathway and thereby enhance the rate of protein synthesis in muscle.

AB - Although insulin, amino acids and exercise individually activate multiple signal transduction pathways in skeletal muscle, one pathway, the phosphatidylinositol 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) signalling pathway, is a target of all three. Activation of the PI3K-mTOR signal transduction pathway results in both acute (i.e. occurring in minutes to hours) and long-term (i.e. occurring in hours to days) up-regulation of protein synthesis through modulation of multiple steps involved in mediating the initiation of mRNA translation and ribosome biogenesis respectively. In addition, changes in gene expression through altered patterns of mRNA translation promote cell growth, which in turn promotes muscle hypertrophy. The focus of the present discussion is to review current knowledge concerning the mechanism(s) through which insulin, amino acids and resistance exercise act to activate the PI3K-mTOR signal transduction pathway and thereby enhance the rate of protein synthesis in muscle.

UR - http://www.scopus.com/inward/record.url?scp=2942733632&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942733632&partnerID=8YFLogxK

U2 - 10.1079/PNS2004355

DO - 10.1079/PNS2004355

M3 - Article

C2 - 15294054

AN - SCOPUS:2942733632

VL - 63

SP - 351

EP - 356

JO - Proceedings of the Nutrition Society

JF - Proceedings of the Nutrition Society

SN - 0029-6651

IS - 2

ER -