Regulation of squamous cell carcinoma carcinogenesis by peroxisome proliferator-activated receptors

Jeffrey M. Peters, Frank J. Gonzalez

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that respond to endogenous and exogenous signaling molecules and modulate cellular functions. PPARs regulate many target genes that in turn influence cell growth, differentiation, and inflammatory signaling. These changes can occur through direct transcriptional up-regulation of target genes, through secondary changes subsequent to direct transcriptional up-regulation of target genes, and through protein-protein interactions. The focus of this chapter is to summarize PPAR-dependent regulation of cellular signaling in squamous epithelium, and how these changes influence cancer.

Original languageEnglish (US)
Title of host publicationSignaling Pathways in Squamous Cancer
PublisherSpringer New York
Pages223-240
Number of pages18
ISBN (Print)9781441972026
DOIs
StatePublished - Dec 1 2011

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Peroxisome Proliferator-Activated Receptors
Squamous Cell Carcinoma
Carcinogenesis
Genes
Up-Regulation
Cell signaling
Cell growth
Cytoplasmic and Nuclear Receptors
Cell Differentiation
Proteins
Epithelium
Molecules
Growth
Epithelial Cells
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Peters, J. M., & Gonzalez, F. J. (2011). Regulation of squamous cell carcinoma carcinogenesis by peroxisome proliferator-activated receptors. In Signaling Pathways in Squamous Cancer (pp. 223-240). Springer New York. https://doi.org/10.1007/978-1-4419-7203-3_11
Peters, Jeffrey M. ; Gonzalez, Frank J. / Regulation of squamous cell carcinoma carcinogenesis by peroxisome proliferator-activated receptors. Signaling Pathways in Squamous Cancer. Springer New York, 2011. pp. 223-240
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Regulation of squamous cell carcinoma carcinogenesis by peroxisome proliferator-activated receptors. / Peters, Jeffrey M.; Gonzalez, Frank J.

Signaling Pathways in Squamous Cancer. Springer New York, 2011. p. 223-240.

Research output: Chapter in Book/Report/Conference proceedingChapter

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