Regulation of the G1-S transition in postembryonic neuronal precursors by axon ingrowth

Scott Brian Selleck, Cayetano Gonzalez, David M. Glover, Kalpana White

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

IN the newly cellularized Drosophila embryo, progress through the cell cycle is regulated at the G2-M transition1,2. We have examined cell-cycle regulation later in Drosophila development, in a group of postembryonic neuronal precursors. The S-phase precursor cells, which generate photoreceptor target neurons (lamina neurons) in the central nervous system, are not present in the absence of photoreceptor innervation3. Here we report that axons selectively approach G1-phase precursors. Without axon ingrowth, lamina precursors do not enter their final S phase and by several criteria, arrest in the preceding G1 phase. These findings provide evidence that at this stage in development the control of cell division can occur at the G1-S transition.

Original languageEnglish (US)
Pages (from-to)253-255
Number of pages3
JournalNature
Volume355
Issue number6357
DOIs
StatePublished - Jan 1 1992

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G1 Phase
S Phase
Drosophila
Axons
Cell Cycle
Neurons
Cell Division
Embryonic Structures
Central Nervous System

All Science Journal Classification (ASJC) codes

  • General

Cite this

Selleck, Scott Brian ; Gonzalez, Cayetano ; Glover, David M. ; White, Kalpana. / Regulation of the G1-S transition in postembryonic neuronal precursors by axon ingrowth. In: Nature. 1992 ; Vol. 355, No. 6357. pp. 253-255.
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Regulation of the G1-S transition in postembryonic neuronal precursors by axon ingrowth. / Selleck, Scott Brian; Gonzalez, Cayetano; Glover, David M.; White, Kalpana.

In: Nature, Vol. 355, No. 6357, 01.01.1992, p. 253-255.

Research output: Contribution to journalArticle

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