Regulation of transcription in expressed and unexpressed mating type cassettes of yeast

Amar J.S. Klar, Jeffrey N. Strathern, James R. Broach, James B. Hicks

Research output: Contribution to journalArticlepeer-review

105 Scopus citations

Abstract

The genes that control the a, α and a/α cell types in Saccharomyces are carried on transposable elements known as a and α cassettes which reside at three different chromosomal loci. Examination of the transcripts by R-looping and filter hybridization indicates that each cassette is capable of producing two divergent transcripts. Cassettes at the MAT locus are transcribed constitutively. Transcription of cassettes at HML and HMR is prevented by trans-acting negative regulators.

Original languageEnglish (US)
Pages (from-to)239-244
Number of pages6
JournalNature
Volume289
Issue number5795
DOIs
StatePublished - Dec 1 1981

All Science Journal Classification (ASJC) codes

  • General

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