Regulatory T cells versus Th17: Differentiation of Th17 versus treg, are they mutually exclusive?

Song Guo Zheng

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Naive CD4+ cells differentiate into T helper (Th1, Th2, Th9, Th17) and regulatory T (Treg) cells to execute their immunologic function. Whereas TGF-B suppresses Th1 and Th2 cell differentiation, this cytokine promotes Th9, Th17, and Foxp3+ regulatory T cells depending upon the existence of other cytokines. IL-6 promotes Th17 but suppresses regulatory T cell differentiation. Moreover, natural but not TGF-B-induced regulatory T cells convert into Th17 cells in the inflammatory milieu. This chapter discusses the updates of these cell differentiation and conversion, as well as underlying mechanisms.

Original languageEnglish (US)
Title of host publicationIL-17, IL-22 and Their Producing Cells
Subtitle of host publicationRole in Inflammation and Autoimmunity
PublisherSpringer Basel
Number of pages17
ISBN (Electronic)9783034805223
ISBN (Print)9783034805216
StatePublished - Jan 1 2013

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Immunology and Microbiology(all)

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