Rejection of human intestinal allografts: Alone or in combination with the liver

K. Abu-Elmagd, S. Todo, A. Tzakis, H. Furukawa, B. Nour, J. Reyes, K. Nakamura, C. Scotti-Foglieni, H. El-Hammadi, Zakiyah Kadry, J. Fung, J. Demetris, T. E. Starzl

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The current results of the present series demonstrate that intestinal allografts are more vulnerable to rejection and continue to be at a significantly higher risk long after transplantation compared with isolated liver allograft recipients. Unexpectedly, a combined liver allograft does not protect small bowel from rejection. The necessarily continuous heavy immunosuppression for these unique recipients is potentially self-defeating. This is clearly demonstrated by their high susceptibility to early and late infectious complications after transplantation as reported in this issue. With the minimal graft-versus-host disease threat in this clinical trial, our revised protocol for future intestinal transplantation is to maximize the passenger leukocyte traffic with supplementary bone marrow from the same intestinal donor in an attempt to augment the development of systemic chimerism and the gradual induction of donor-specific nonreactivity.

Original languageEnglish (US)
Pages (from-to)1430-1431
Number of pages2
JournalTransplantation proceedings
Volume26
Issue number3
StatePublished - Jul 15 1994

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Allografts
Transplantation
Liver
Chimerism
Graft vs Host Disease
Immunosuppression
Leukocytes
Bone Marrow
Clinical Trials

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Abu-Elmagd, K., Todo, S., Tzakis, A., Furukawa, H., Nour, B., Reyes, J., ... Starzl, T. E. (1994). Rejection of human intestinal allografts: Alone or in combination with the liver. Transplantation proceedings, 26(3), 1430-1431.
Abu-Elmagd, K. ; Todo, S. ; Tzakis, A. ; Furukawa, H. ; Nour, B. ; Reyes, J. ; Nakamura, K. ; Scotti-Foglieni, C. ; El-Hammadi, H. ; Kadry, Zakiyah ; Fung, J. ; Demetris, J. ; Starzl, T. E. / Rejection of human intestinal allografts : Alone or in combination with the liver. In: Transplantation proceedings. 1994 ; Vol. 26, No. 3. pp. 1430-1431.
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Abu-Elmagd, K, Todo, S, Tzakis, A, Furukawa, H, Nour, B, Reyes, J, Nakamura, K, Scotti-Foglieni, C, El-Hammadi, H, Kadry, Z, Fung, J, Demetris, J & Starzl, TE 1994, 'Rejection of human intestinal allografts: Alone or in combination with the liver', Transplantation proceedings, vol. 26, no. 3, pp. 1430-1431.

Rejection of human intestinal allografts : Alone or in combination with the liver. / Abu-Elmagd, K.; Todo, S.; Tzakis, A.; Furukawa, H.; Nour, B.; Reyes, J.; Nakamura, K.; Scotti-Foglieni, C.; El-Hammadi, H.; Kadry, Zakiyah; Fung, J.; Demetris, J.; Starzl, T. E.

In: Transplantation proceedings, Vol. 26, No. 3, 15.07.1994, p. 1430-1431.

Research output: Contribution to journalArticle

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T1 - Rejection of human intestinal allografts

T2 - Alone or in combination with the liver

AU - Abu-Elmagd, K.

AU - Todo, S.

AU - Tzakis, A.

AU - Furukawa, H.

AU - Nour, B.

AU - Reyes, J.

AU - Nakamura, K.

AU - Scotti-Foglieni, C.

AU - El-Hammadi, H.

AU - Kadry, Zakiyah

AU - Fung, J.

AU - Demetris, J.

AU - Starzl, T. E.

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Y1 - 1994/7/15

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AB - The current results of the present series demonstrate that intestinal allografts are more vulnerable to rejection and continue to be at a significantly higher risk long after transplantation compared with isolated liver allograft recipients. Unexpectedly, a combined liver allograft does not protect small bowel from rejection. The necessarily continuous heavy immunosuppression for these unique recipients is potentially self-defeating. This is clearly demonstrated by their high susceptibility to early and late infectious complications after transplantation as reported in this issue. With the minimal graft-versus-host disease threat in this clinical trial, our revised protocol for future intestinal transplantation is to maximize the passenger leukocyte traffic with supplementary bone marrow from the same intestinal donor in an attempt to augment the development of systemic chimerism and the gradual induction of donor-specific nonreactivity.

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Abu-Elmagd K, Todo S, Tzakis A, Furukawa H, Nour B, Reyes J et al. Rejection of human intestinal allografts: Alone or in combination with the liver. Transplantation proceedings. 1994 Jul 15;26(3):1430-1431.