Relationship between acute phase of inflammatory response (APIR) and oxidative stress (OS) was studied in patients with acquired heart diseases. 58 patients with acquired heart diseases were investigated before and after operations on open heart. Intensity of APIR was evaluated according to concentrations of C-reactive protein, α1-antitrypsin, α2-macroglobulin and albumin; OS was studied according to indices of malonic aldehyde, coupled triens, ceruloplasmin and plasma catalase. It is shown that cardiosurgical intervention leads to marked APIR and OS on first postoperative day with further reduction of their intensity on 3-4 and 10-12 days after operation. The highest level of APIR corresponded with maximum intensity of OS. Direct correlations between acute phase proteins and lipid peroxidation metabolites were estimated. It is drawn a conclusion that APIR and OS are mutually potentiating and straightly depend on duration of perfusion and myocardial ischemia.
|Original language||English (US)|
|Number of pages||4|
|Journal||Kardiologiya i Serdechno-Sosudistaya Khirurgiya|
|State||Published - 2012|
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine