Relationship between free-living daily physical activity and peripheral circulation in patients with intermittent claudication

Andrew W. Gardner, Lois A. Killewich, Leslie I. Katzel, Christopher J. Womack, Polly S. Montgomery, Rosemary B. Otis, Tekum Fonong

Research output: Contribution to journalArticle

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Abstract

The purpose of this study was to determine the relationship between free-living daily physical activity and peripheral circulation under resting, reactive hyperemia, and maximal exercise conditions in peripheral arterial occlusive disease (PAOD) patients with intermittent claudication. Sixty-one PAOD patients (age=70 ±6 years, ankle/brachial index [ABI] =0.57 ± 0.24) were recruited from the Vascular Clinic at the Baltimore Veterans Affairs Medical Center and from radio and newspaper advertisements. Free-living daily physical activity was measured as the energy expenditure of physical activity (EEPA), determined from doubly labeled water and indirect calorimetry. Patients also were characterized on ankle/brachial index, calf blood flow, calf transcutaneous oxygen tension (TcPo2), and calf transcutaneous heating power (TcHP). ABI and calf blood flow served as markers of the macrocirculation of the lower extremity, while TcPo2 and TcHP served as markers of the microcirculation. The claudication patients were sedentary, reflected by a mean EEPA value of 486 ± 274 kcal/day. EEPA was related to calf TcHP at rest (282 ± 24 mW; r=-0.413, p=0.002), after postocclusion reactive hyperemia (275 ± 22 mW; r=-0.381, p=0.004), and after maximal exercise (276 ± 20 mW; r=-0.461, p<0.001). ABI, calf blood flow, and calf TcPo2 were not related to EEPA under any condition. In conclusion, higher levels of free-living daily physical activity were associated with better microcirculation of the calf musculature in older PAOD patients with intermittent claudication.

Original languageEnglish (US)
Pages (from-to)289-297
Number of pages9
JournalAngiology
Volume50
Issue number4
DOIs
StatePublished - Apr 1999

Fingerprint

Intermittent Claudication
Exercise
Ankle Brachial Index
Arterial Occlusive Diseases
Energy Metabolism
Peripheral Arterial Disease
Heating
Hyperemia
Microcirculation
Indirect Calorimetry
Baltimore
Newspapers
Veterans
Radio
Blood Vessels
Lower Extremity
Oxygen
Water

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Gardner, Andrew W. ; Killewich, Lois A. ; Katzel, Leslie I. ; Womack, Christopher J. ; Montgomery, Polly S. ; Otis, Rosemary B. ; Fonong, Tekum. / Relationship between free-living daily physical activity and peripheral circulation in patients with intermittent claudication. In: Angiology. 1999 ; Vol. 50, No. 4. pp. 289-297.
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Relationship between free-living daily physical activity and peripheral circulation in patients with intermittent claudication. / Gardner, Andrew W.; Killewich, Lois A.; Katzel, Leslie I.; Womack, Christopher J.; Montgomery, Polly S.; Otis, Rosemary B.; Fonong, Tekum.

In: Angiology, Vol. 50, No. 4, 04.1999, p. 289-297.

Research output: Contribution to journalArticle

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AU - Killewich, Lois A.

AU - Katzel, Leslie I.

AU - Womack, Christopher J.

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N2 - The purpose of this study was to determine the relationship between free-living daily physical activity and peripheral circulation under resting, reactive hyperemia, and maximal exercise conditions in peripheral arterial occlusive disease (PAOD) patients with intermittent claudication. Sixty-one PAOD patients (age=70 ±6 years, ankle/brachial index [ABI] =0.57 ± 0.24) were recruited from the Vascular Clinic at the Baltimore Veterans Affairs Medical Center and from radio and newspaper advertisements. Free-living daily physical activity was measured as the energy expenditure of physical activity (EEPA), determined from doubly labeled water and indirect calorimetry. Patients also were characterized on ankle/brachial index, calf blood flow, calf transcutaneous oxygen tension (TcPo2), and calf transcutaneous heating power (TcHP). ABI and calf blood flow served as markers of the macrocirculation of the lower extremity, while TcPo2 and TcHP served as markers of the microcirculation. The claudication patients were sedentary, reflected by a mean EEPA value of 486 ± 274 kcal/day. EEPA was related to calf TcHP at rest (282 ± 24 mW; r=-0.413, p=0.002), after postocclusion reactive hyperemia (275 ± 22 mW; r=-0.381, p=0.004), and after maximal exercise (276 ± 20 mW; r=-0.461, p<0.001). ABI, calf blood flow, and calf TcPo2 were not related to EEPA under any condition. In conclusion, higher levels of free-living daily physical activity were associated with better microcirculation of the calf musculature in older PAOD patients with intermittent claudication.

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