Relationship between frontal lobe lesions and Wisconsin card sorting test performance in patients with multiple sclerosis

Peter A. Arnett, S. M. Rao, L. Bernardin, J. Grafman, F. Z. Yetkin, L. Lobeck

Research output: Contribution to journalArticle

257 Citations (Scopus)

Abstract

Conceptual reasoning deficits are common in patients with multiple sclerosis (MS) and are typically associated with focal lesions involving the frontal lobes. In this study, we predicted that MS patients with frontal white matter lesions (MS-F) would be more impaired on a standard conceptual reasoning task (Wisconsin Card Sorting Test; WCST) than patients with minimal frontal lesions (MS-NF), even if the total cerebral lesion area (TLA), measured from MRI, was equivalent across groups. We subdivided 43 definite MS patients into three groups based on MRI findings: seven in the MS-F group (mean TLA = 41.4 cm2) and seven in the MS-NF group (mean TLA = 50.0 cm2); 29 MS patients served as a low lesion burden control group (MS-C; mean TLA = 6.4 cm2). The groups did not differ with regard to demographic and illness characteristics. Although the three subgroups obtained comparable scores on a measure of global cognitive functioning (verbal intelligence), the MS-F group achieved significantly fewer categories and made more total errors on the WCST than did the MS-NF and MS-C groups. The MS-F group made significantly more perseverative responses than the MS-C group and nonsignificantly more than the MS-NF group. These results suggest that the pattern of cognitive decline in MS is a function of the location of demyelinating lesions within the cerebral hemispheric white matter. Finally, we supplement the group study results with a case report of an MS patient who was studied serially with MRI and cognitive testing.

Original languageEnglish (US)
Pages (from-to)420-425
Number of pages6
JournalNeurology
Volume44
Issue number3
StatePublished - Mar 1994

Fingerprint

Frontal Lobe
Multiple Sclerosis
Performance Test
Lesion
Intelligence

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Arnett, P. A., Rao, S. M., Bernardin, L., Grafman, J., Yetkin, F. Z., & Lobeck, L. (1994). Relationship between frontal lobe lesions and Wisconsin card sorting test performance in patients with multiple sclerosis. Neurology, 44(3), 420-425.
Arnett, Peter A. ; Rao, S. M. ; Bernardin, L. ; Grafman, J. ; Yetkin, F. Z. ; Lobeck, L. / Relationship between frontal lobe lesions and Wisconsin card sorting test performance in patients with multiple sclerosis. In: Neurology. 1994 ; Vol. 44, No. 3. pp. 420-425.
@article{d4396b57b18a4a58abde1bc69c79054b,
title = "Relationship between frontal lobe lesions and Wisconsin card sorting test performance in patients with multiple sclerosis",
abstract = "Conceptual reasoning deficits are common in patients with multiple sclerosis (MS) and are typically associated with focal lesions involving the frontal lobes. In this study, we predicted that MS patients with frontal white matter lesions (MS-F) would be more impaired on a standard conceptual reasoning task (Wisconsin Card Sorting Test; WCST) than patients with minimal frontal lesions (MS-NF), even if the total cerebral lesion area (TLA), measured from MRI, was equivalent across groups. We subdivided 43 definite MS patients into three groups based on MRI findings: seven in the MS-F group (mean TLA = 41.4 cm2) and seven in the MS-NF group (mean TLA = 50.0 cm2); 29 MS patients served as a low lesion burden control group (MS-C; mean TLA = 6.4 cm2). The groups did not differ with regard to demographic and illness characteristics. Although the three subgroups obtained comparable scores on a measure of global cognitive functioning (verbal intelligence), the MS-F group achieved significantly fewer categories and made more total errors on the WCST than did the MS-NF and MS-C groups. The MS-F group made significantly more perseverative responses than the MS-C group and nonsignificantly more than the MS-NF group. These results suggest that the pattern of cognitive decline in MS is a function of the location of demyelinating lesions within the cerebral hemispheric white matter. Finally, we supplement the group study results with a case report of an MS patient who was studied serially with MRI and cognitive testing.",
author = "Arnett, {Peter A.} and Rao, {S. M.} and L. Bernardin and J. Grafman and Yetkin, {F. Z.} and L. Lobeck",
year = "1994",
month = "3",
language = "English (US)",
volume = "44",
pages = "420--425",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

Arnett, PA, Rao, SM, Bernardin, L, Grafman, J, Yetkin, FZ & Lobeck, L 1994, 'Relationship between frontal lobe lesions and Wisconsin card sorting test performance in patients with multiple sclerosis', Neurology, vol. 44, no. 3, pp. 420-425.

Relationship between frontal lobe lesions and Wisconsin card sorting test performance in patients with multiple sclerosis. / Arnett, Peter A.; Rao, S. M.; Bernardin, L.; Grafman, J.; Yetkin, F. Z.; Lobeck, L.

In: Neurology, Vol. 44, No. 3, 03.1994, p. 420-425.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship between frontal lobe lesions and Wisconsin card sorting test performance in patients with multiple sclerosis

AU - Arnett, Peter A.

AU - Rao, S. M.

AU - Bernardin, L.

AU - Grafman, J.

AU - Yetkin, F. Z.

AU - Lobeck, L.

PY - 1994/3

Y1 - 1994/3

N2 - Conceptual reasoning deficits are common in patients with multiple sclerosis (MS) and are typically associated with focal lesions involving the frontal lobes. In this study, we predicted that MS patients with frontal white matter lesions (MS-F) would be more impaired on a standard conceptual reasoning task (Wisconsin Card Sorting Test; WCST) than patients with minimal frontal lesions (MS-NF), even if the total cerebral lesion area (TLA), measured from MRI, was equivalent across groups. We subdivided 43 definite MS patients into three groups based on MRI findings: seven in the MS-F group (mean TLA = 41.4 cm2) and seven in the MS-NF group (mean TLA = 50.0 cm2); 29 MS patients served as a low lesion burden control group (MS-C; mean TLA = 6.4 cm2). The groups did not differ with regard to demographic and illness characteristics. Although the three subgroups obtained comparable scores on a measure of global cognitive functioning (verbal intelligence), the MS-F group achieved significantly fewer categories and made more total errors on the WCST than did the MS-NF and MS-C groups. The MS-F group made significantly more perseverative responses than the MS-C group and nonsignificantly more than the MS-NF group. These results suggest that the pattern of cognitive decline in MS is a function of the location of demyelinating lesions within the cerebral hemispheric white matter. Finally, we supplement the group study results with a case report of an MS patient who was studied serially with MRI and cognitive testing.

AB - Conceptual reasoning deficits are common in patients with multiple sclerosis (MS) and are typically associated with focal lesions involving the frontal lobes. In this study, we predicted that MS patients with frontal white matter lesions (MS-F) would be more impaired on a standard conceptual reasoning task (Wisconsin Card Sorting Test; WCST) than patients with minimal frontal lesions (MS-NF), even if the total cerebral lesion area (TLA), measured from MRI, was equivalent across groups. We subdivided 43 definite MS patients into three groups based on MRI findings: seven in the MS-F group (mean TLA = 41.4 cm2) and seven in the MS-NF group (mean TLA = 50.0 cm2); 29 MS patients served as a low lesion burden control group (MS-C; mean TLA = 6.4 cm2). The groups did not differ with regard to demographic and illness characteristics. Although the three subgroups obtained comparable scores on a measure of global cognitive functioning (verbal intelligence), the MS-F group achieved significantly fewer categories and made more total errors on the WCST than did the MS-NF and MS-C groups. The MS-F group made significantly more perseverative responses than the MS-C group and nonsignificantly more than the MS-NF group. These results suggest that the pattern of cognitive decline in MS is a function of the location of demyelinating lesions within the cerebral hemispheric white matter. Finally, we supplement the group study results with a case report of an MS patient who was studied serially with MRI and cognitive testing.

UR - http://www.scopus.com/inward/record.url?scp=0028271332&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028271332&partnerID=8YFLogxK

M3 - Article

C2 - 8145908

AN - SCOPUS:0028271332

VL - 44

SP - 420

EP - 425

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 3

ER -