Relationship between objective measures of peripheral arterial disease severity to self-reported quality of life in older adults with intermittent claudication

Anna Maria Izquierdo-Porrera, Andrew Gardner, Douglas D. Bradham, Polly S. Montgomery, John D. Sorkin, Claudia C. Powell, Leslie I. Katzel

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Objectives: The aim of this study was to determine the relation between functional measures of peripheral arterial disease (PAD) severity with both disease-specific and generic self-reported health-related quality-of-life (HR-QOL) measures, as well as the relation between the two types of HR-QOL measures. Methods: This was a cross-sectional observation of participants from the community and primary care or vascular surgery clinics in an academic Veterans Administration medical center. Eighty patients with symptomatic Fontaine stage II PAD provided physiologic measures and self-response questionnaires. Objective measures included the ankle-brachial index (ABI), time to maximum claudication pain on a graded exercise test, and a 6-minute floor-walking distance. Self-reports included the Walking Impairment Questionnaire (WIQ), a disease-specific HR-QOL measure and the Medical Outcomes Study (MOS) Short-Form 36 (SF-36), a generic HR-QOL measure. Results: Patients (mean age 70 ± 8 [± SD] and 85% men) exhibited moderate-to-severe PAD by objective measures of ABI (0.65 ± 0.19) and time in minutes to maximal claudication on a graded exercise test (7:54 ± 4:58). Significant correlations were found between these measures and the WIQ distance, MOS-Physical Function, and MOS-Role Limitations due to physical dysfunction. The SF-36 and the WIQ subscales were significantly correlated. Conclusion: In older PAD patients with intermittent claudication, objective measures of disease severity are correlated with a self-reported, disease-specific and generic HR-QOL.

Original languageEnglish (US)
Pages (from-to)625-630
Number of pages6
JournalJournal of Vascular Surgery
Volume41
Issue number4
DOIs
StatePublished - Apr 1 2005

Fingerprint

Intermittent Claudication
Peripheral Arterial Disease
Quality of Life
Walking
Ankle Brachial Index
Outcome Assessment (Health Care)
Exercise Test
United States Department of Veterans Affairs
Self Report
Blood Vessels
Primary Health Care
Observation
Pain
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Izquierdo-Porrera, Anna Maria ; Gardner, Andrew ; Bradham, Douglas D. ; Montgomery, Polly S. ; Sorkin, John D. ; Powell, Claudia C. ; Katzel, Leslie I. / Relationship between objective measures of peripheral arterial disease severity to self-reported quality of life in older adults with intermittent claudication. In: Journal of Vascular Surgery. 2005 ; Vol. 41, No. 4. pp. 625-630.
@article{602c1e1779644711a2d89ba4337b9114,
title = "Relationship between objective measures of peripheral arterial disease severity to self-reported quality of life in older adults with intermittent claudication",
abstract = "Objectives: The aim of this study was to determine the relation between functional measures of peripheral arterial disease (PAD) severity with both disease-specific and generic self-reported health-related quality-of-life (HR-QOL) measures, as well as the relation between the two types of HR-QOL measures. Methods: This was a cross-sectional observation of participants from the community and primary care or vascular surgery clinics in an academic Veterans Administration medical center. Eighty patients with symptomatic Fontaine stage II PAD provided physiologic measures and self-response questionnaires. Objective measures included the ankle-brachial index (ABI), time to maximum claudication pain on a graded exercise test, and a 6-minute floor-walking distance. Self-reports included the Walking Impairment Questionnaire (WIQ), a disease-specific HR-QOL measure and the Medical Outcomes Study (MOS) Short-Form 36 (SF-36), a generic HR-QOL measure. Results: Patients (mean age 70 ± 8 [± SD] and 85{\%} men) exhibited moderate-to-severe PAD by objective measures of ABI (0.65 ± 0.19) and time in minutes to maximal claudication on a graded exercise test (7:54 ± 4:58). Significant correlations were found between these measures and the WIQ distance, MOS-Physical Function, and MOS-Role Limitations due to physical dysfunction. The SF-36 and the WIQ subscales were significantly correlated. Conclusion: In older PAD patients with intermittent claudication, objective measures of disease severity are correlated with a self-reported, disease-specific and generic HR-QOL.",
author = "Izquierdo-Porrera, {Anna Maria} and Andrew Gardner and Bradham, {Douglas D.} and Montgomery, {Polly S.} and Sorkin, {John D.} and Powell, {Claudia C.} and Katzel, {Leslie I.}",
year = "2005",
month = "4",
day = "1",
doi = "10.1016/j.jvs.2005.01.012",
language = "English (US)",
volume = "41",
pages = "625--630",
journal = "Journal of Vascular Surgery",
issn = "0741-5214",
publisher = "Mosby Inc.",
number = "4",

}

Relationship between objective measures of peripheral arterial disease severity to self-reported quality of life in older adults with intermittent claudication. / Izquierdo-Porrera, Anna Maria; Gardner, Andrew; Bradham, Douglas D.; Montgomery, Polly S.; Sorkin, John D.; Powell, Claudia C.; Katzel, Leslie I.

In: Journal of Vascular Surgery, Vol. 41, No. 4, 01.04.2005, p. 625-630.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship between objective measures of peripheral arterial disease severity to self-reported quality of life in older adults with intermittent claudication

AU - Izquierdo-Porrera, Anna Maria

AU - Gardner, Andrew

AU - Bradham, Douglas D.

AU - Montgomery, Polly S.

AU - Sorkin, John D.

AU - Powell, Claudia C.

AU - Katzel, Leslie I.

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Objectives: The aim of this study was to determine the relation between functional measures of peripheral arterial disease (PAD) severity with both disease-specific and generic self-reported health-related quality-of-life (HR-QOL) measures, as well as the relation between the two types of HR-QOL measures. Methods: This was a cross-sectional observation of participants from the community and primary care or vascular surgery clinics in an academic Veterans Administration medical center. Eighty patients with symptomatic Fontaine stage II PAD provided physiologic measures and self-response questionnaires. Objective measures included the ankle-brachial index (ABI), time to maximum claudication pain on a graded exercise test, and a 6-minute floor-walking distance. Self-reports included the Walking Impairment Questionnaire (WIQ), a disease-specific HR-QOL measure and the Medical Outcomes Study (MOS) Short-Form 36 (SF-36), a generic HR-QOL measure. Results: Patients (mean age 70 ± 8 [± SD] and 85% men) exhibited moderate-to-severe PAD by objective measures of ABI (0.65 ± 0.19) and time in minutes to maximal claudication on a graded exercise test (7:54 ± 4:58). Significant correlations were found between these measures and the WIQ distance, MOS-Physical Function, and MOS-Role Limitations due to physical dysfunction. The SF-36 and the WIQ subscales were significantly correlated. Conclusion: In older PAD patients with intermittent claudication, objective measures of disease severity are correlated with a self-reported, disease-specific and generic HR-QOL.

AB - Objectives: The aim of this study was to determine the relation between functional measures of peripheral arterial disease (PAD) severity with both disease-specific and generic self-reported health-related quality-of-life (HR-QOL) measures, as well as the relation between the two types of HR-QOL measures. Methods: This was a cross-sectional observation of participants from the community and primary care or vascular surgery clinics in an academic Veterans Administration medical center. Eighty patients with symptomatic Fontaine stage II PAD provided physiologic measures and self-response questionnaires. Objective measures included the ankle-brachial index (ABI), time to maximum claudication pain on a graded exercise test, and a 6-minute floor-walking distance. Self-reports included the Walking Impairment Questionnaire (WIQ), a disease-specific HR-QOL measure and the Medical Outcomes Study (MOS) Short-Form 36 (SF-36), a generic HR-QOL measure. Results: Patients (mean age 70 ± 8 [± SD] and 85% men) exhibited moderate-to-severe PAD by objective measures of ABI (0.65 ± 0.19) and time in minutes to maximal claudication on a graded exercise test (7:54 ± 4:58). Significant correlations were found between these measures and the WIQ distance, MOS-Physical Function, and MOS-Role Limitations due to physical dysfunction. The SF-36 and the WIQ subscales were significantly correlated. Conclusion: In older PAD patients with intermittent claudication, objective measures of disease severity are correlated with a self-reported, disease-specific and generic HR-QOL.

UR - http://www.scopus.com/inward/record.url?scp=18344380106&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18344380106&partnerID=8YFLogxK

U2 - 10.1016/j.jvs.2005.01.012

DO - 10.1016/j.jvs.2005.01.012

M3 - Article

VL - 41

SP - 625

EP - 630

JO - Journal of Vascular Surgery

JF - Journal of Vascular Surgery

SN - 0741-5214

IS - 4

ER -