Relationship between types of common channel and development of biliary tract cancer pancreaticobiliary maljunction

Hitoshi Hara, Shinsho Morita, Shozo Sako, Takehiko Dohi, Masahiro Otani, Mitsuhiko Iwamoto, Hitoshi Inoue, Nobuhiko Tanigawa

Research output: Contribution to journalArticle

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Abstract

Background/Aims: The incidence of biliary tract cancer development is high among patients with pancreaticobiliary maljunction. However, there have been no reports published evaluating the incidence of development of biliary tract cancers in pancreaticobiliary maljunction based on the morphology of the common channel at the junction of the bile and pancreatic ducts. We evaluated between types of common channel and development of biliary tract cancers in pancreaticobiliary maljunction. Methodology: During the last 21 years, we have experienced 78 patients with pancreaticobiliary maljunction. Of those patients, 44 adult patients, whose morphologic types of common channel were identified by cholangiography, were enrolled in this study. The dilatation patterns of the common channel were classified into 3 types: A type (moderately dilated type), B type (markedly dilated type), and C type (non-dilated type). Evaluated items included the length and dilation patterns of the common channel, incidence of development of biliary tract cancers and proliferative activity in the biliary tract epithelium. Results: Seventeen patients had a common channel shorter than 20mm, while 27 had a common channel of 20mm or longer. Eleven patients with a common channel of 20mm or longer had development of bile tract cancers. The dilation patterns of the common channel were classified as A (11 patients), B (16 patients) and C type (17 patients). Amylase levels in the biliary tract were higher in patients with A and B type than in patients with the C type. Development of gallbladder cancer was observed in 6 patients with A, 2 patients with B and one patient with C, while development of bile duct cancer was observed in 2 patients with C and one patient with B. The PCNAL.I. of the biliary epithelium was higher in patients with A, B and C type in descending order. Conclusions: The incidence of development of biliary tract cancer was higher in patients with common channel of 20mm or longer. The proliferative activity in the biliary epithelium was accelerated in patients with A type, together with a high incidence of development of gallbladder cancer.

Original languageEnglish (US)
Pages (from-to)322-325
Number of pages4
JournalHepato-Gastroenterology
Volume49
Issue number44
StatePublished - Jan 1 2002

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Biliary Tract Neoplasms
Incidence
Gallbladder Neoplasms
Dilatation
Epithelium
Biliary Tract
Bile Duct Neoplasms

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Hara, H., Morita, S., Sako, S., Dohi, T., Otani, M., Iwamoto, M., ... Tanigawa, N. (2002). Relationship between types of common channel and development of biliary tract cancer pancreaticobiliary maljunction. Hepato-Gastroenterology, 49(44), 322-325.
Hara, Hitoshi ; Morita, Shinsho ; Sako, Shozo ; Dohi, Takehiko ; Otani, Masahiro ; Iwamoto, Mitsuhiko ; Inoue, Hitoshi ; Tanigawa, Nobuhiko. / Relationship between types of common channel and development of biliary tract cancer pancreaticobiliary maljunction. In: Hepato-Gastroenterology. 2002 ; Vol. 49, No. 44. pp. 322-325.
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abstract = "Background/Aims: The incidence of biliary tract cancer development is high among patients with pancreaticobiliary maljunction. However, there have been no reports published evaluating the incidence of development of biliary tract cancers in pancreaticobiliary maljunction based on the morphology of the common channel at the junction of the bile and pancreatic ducts. We evaluated between types of common channel and development of biliary tract cancers in pancreaticobiliary maljunction. Methodology: During the last 21 years, we have experienced 78 patients with pancreaticobiliary maljunction. Of those patients, 44 adult patients, whose morphologic types of common channel were identified by cholangiography, were enrolled in this study. The dilatation patterns of the common channel were classified into 3 types: A type (moderately dilated type), B type (markedly dilated type), and C type (non-dilated type). Evaluated items included the length and dilation patterns of the common channel, incidence of development of biliary tract cancers and proliferative activity in the biliary tract epithelium. Results: Seventeen patients had a common channel shorter than 20mm, while 27 had a common channel of 20mm or longer. Eleven patients with a common channel of 20mm or longer had development of bile tract cancers. The dilation patterns of the common channel were classified as A (11 patients), B (16 patients) and C type (17 patients). Amylase levels in the biliary tract were higher in patients with A and B type than in patients with the C type. Development of gallbladder cancer was observed in 6 patients with A, 2 patients with B and one patient with C, while development of bile duct cancer was observed in 2 patients with C and one patient with B. The PCNAL.I. of the biliary epithelium was higher in patients with A, B and C type in descending order. Conclusions: The incidence of development of biliary tract cancer was higher in patients with common channel of 20mm or longer. The proliferative activity in the biliary epithelium was accelerated in patients with A type, together with a high incidence of development of gallbladder cancer.",
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Hara, H, Morita, S, Sako, S, Dohi, T, Otani, M, Iwamoto, M, Inoue, H & Tanigawa, N 2002, 'Relationship between types of common channel and development of biliary tract cancer pancreaticobiliary maljunction', Hepato-Gastroenterology, vol. 49, no. 44, pp. 322-325.

Relationship between types of common channel and development of biliary tract cancer pancreaticobiliary maljunction. / Hara, Hitoshi; Morita, Shinsho; Sako, Shozo; Dohi, Takehiko; Otani, Masahiro; Iwamoto, Mitsuhiko; Inoue, Hitoshi; Tanigawa, Nobuhiko.

In: Hepato-Gastroenterology, Vol. 49, No. 44, 01.01.2002, p. 322-325.

Research output: Contribution to journalArticle

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T1 - Relationship between types of common channel and development of biliary tract cancer pancreaticobiliary maljunction

AU - Hara, Hitoshi

AU - Morita, Shinsho

AU - Sako, Shozo

AU - Dohi, Takehiko

AU - Otani, Masahiro

AU - Iwamoto, Mitsuhiko

AU - Inoue, Hitoshi

AU - Tanigawa, Nobuhiko

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Background/Aims: The incidence of biliary tract cancer development is high among patients with pancreaticobiliary maljunction. However, there have been no reports published evaluating the incidence of development of biliary tract cancers in pancreaticobiliary maljunction based on the morphology of the common channel at the junction of the bile and pancreatic ducts. We evaluated between types of common channel and development of biliary tract cancers in pancreaticobiliary maljunction. Methodology: During the last 21 years, we have experienced 78 patients with pancreaticobiliary maljunction. Of those patients, 44 adult patients, whose morphologic types of common channel were identified by cholangiography, were enrolled in this study. The dilatation patterns of the common channel were classified into 3 types: A type (moderately dilated type), B type (markedly dilated type), and C type (non-dilated type). Evaluated items included the length and dilation patterns of the common channel, incidence of development of biliary tract cancers and proliferative activity in the biliary tract epithelium. Results: Seventeen patients had a common channel shorter than 20mm, while 27 had a common channel of 20mm or longer. Eleven patients with a common channel of 20mm or longer had development of bile tract cancers. The dilation patterns of the common channel were classified as A (11 patients), B (16 patients) and C type (17 patients). Amylase levels in the biliary tract were higher in patients with A and B type than in patients with the C type. Development of gallbladder cancer was observed in 6 patients with A, 2 patients with B and one patient with C, while development of bile duct cancer was observed in 2 patients with C and one patient with B. The PCNAL.I. of the biliary epithelium was higher in patients with A, B and C type in descending order. Conclusions: The incidence of development of biliary tract cancer was higher in patients with common channel of 20mm or longer. The proliferative activity in the biliary epithelium was accelerated in patients with A type, together with a high incidence of development of gallbladder cancer.

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