Relationship of creatine kinase to body composition, disease state, and longevity in ALS

Summer B. Gibson, Edward J. Kasarskis, Nan Hu, Stefan M. Pulst, Marta S. Mendiondo, Dwight E. Matthews, Hiroshi Mitsumoto, Rup Tandan, Zachary Simmons, Richard J. Kryscio, Mark B. Bromberg

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Our objective was to explore if creatine kinase (CK) levels correlate with survival in amyotrophic lateral sclerosis (ALS), and whether a correlation is independent of other well-studied predictors such as location of onset, gender, age, fat free mass, spasticity, cramps, and fasciculations. We analyzed data from 80 ALS patients from a 48-week non-interventional longitudinal multicenter nutrition study with long term follow-up. The overall mean CK was 214 ± 191.8 U/l (range 22-1992 U/l). Forty-five percent of patients had at least one high CK value (> 200 U/l), and about half maintained a high CK value, but there was no trend over the study period. Male gender and extremity onset were significantly associated with high CK. In univariate analysis, age, bioelectric impedance spectroscopy (BIS) fat free mass, spasticity, and fasciculations were not associated with CK level. There was an association between CK and muscle cramps (p < 0.001). In survival analysis, low CK (≤ 200 U/l) was associated with a longer overall survival (p = 0.02), when adjusting for location of onset, age, race, gender, BIS fat free mass, and study site. In conclusion, CK may be a useful marker for ALS survival, which has implications for clinical care and the design of future clinical trials.

Original languageEnglish (US)
Pages (from-to)473-477
Number of pages5
JournalAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Volume16
Issue number7-8
DOIs
StatePublished - Nov 27 2015

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Amyotrophic Lateral Sclerosis
Creatine Kinase
Body Composition
Fasciculation
Dielectric Spectroscopy
Muscle Cramp
Fats
Age of Onset
Survival
Survival Analysis
Multicenter Studies
Extremities
Clinical Trials

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Gibson, S. B., Kasarskis, E. J., Hu, N., Pulst, S. M., Mendiondo, M. S., Matthews, D. E., ... Bromberg, M. B. (2015). Relationship of creatine kinase to body composition, disease state, and longevity in ALS. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16(7-8), 473-477. https://doi.org/10.3109/21678421.2015.1062516
Gibson, Summer B. ; Kasarskis, Edward J. ; Hu, Nan ; Pulst, Stefan M. ; Mendiondo, Marta S. ; Matthews, Dwight E. ; Mitsumoto, Hiroshi ; Tandan, Rup ; Simmons, Zachary ; Kryscio, Richard J. ; Bromberg, Mark B. / Relationship of creatine kinase to body composition, disease state, and longevity in ALS. In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 2015 ; Vol. 16, No. 7-8. pp. 473-477.
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Gibson, SB, Kasarskis, EJ, Hu, N, Pulst, SM, Mendiondo, MS, Matthews, DE, Mitsumoto, H, Tandan, R, Simmons, Z, Kryscio, RJ & Bromberg, MB 2015, 'Relationship of creatine kinase to body composition, disease state, and longevity in ALS', Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, vol. 16, no. 7-8, pp. 473-477. https://doi.org/10.3109/21678421.2015.1062516

Relationship of creatine kinase to body composition, disease state, and longevity in ALS. / Gibson, Summer B.; Kasarskis, Edward J.; Hu, Nan; Pulst, Stefan M.; Mendiondo, Marta S.; Matthews, Dwight E.; Mitsumoto, Hiroshi; Tandan, Rup; Simmons, Zachary; Kryscio, Richard J.; Bromberg, Mark B.

In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Vol. 16, No. 7-8, 27.11.2015, p. 473-477.

Research output: Contribution to journalArticle

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T1 - Relationship of creatine kinase to body composition, disease state, and longevity in ALS

AU - Gibson, Summer B.

AU - Kasarskis, Edward J.

AU - Hu, Nan

AU - Pulst, Stefan M.

AU - Mendiondo, Marta S.

AU - Matthews, Dwight E.

AU - Mitsumoto, Hiroshi

AU - Tandan, Rup

AU - Simmons, Zachary

AU - Kryscio, Richard J.

AU - Bromberg, Mark B.

PY - 2015/11/27

Y1 - 2015/11/27

N2 - Our objective was to explore if creatine kinase (CK) levels correlate with survival in amyotrophic lateral sclerosis (ALS), and whether a correlation is independent of other well-studied predictors such as location of onset, gender, age, fat free mass, spasticity, cramps, and fasciculations. We analyzed data from 80 ALS patients from a 48-week non-interventional longitudinal multicenter nutrition study with long term follow-up. The overall mean CK was 214 ± 191.8 U/l (range 22-1992 U/l). Forty-five percent of patients had at least one high CK value (> 200 U/l), and about half maintained a high CK value, but there was no trend over the study period. Male gender and extremity onset were significantly associated with high CK. In univariate analysis, age, bioelectric impedance spectroscopy (BIS) fat free mass, spasticity, and fasciculations were not associated with CK level. There was an association between CK and muscle cramps (p < 0.001). In survival analysis, low CK (≤ 200 U/l) was associated with a longer overall survival (p = 0.02), when adjusting for location of onset, age, race, gender, BIS fat free mass, and study site. In conclusion, CK may be a useful marker for ALS survival, which has implications for clinical care and the design of future clinical trials.

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