TY - JOUR
T1 - Relationship of creatine kinase to body composition, disease state, and longevity in ALS
AU - Gibson, Summer B.
AU - Kasarskis, Edward J.
AU - Hu, Nan
AU - Pulst, Stefan M.
AU - Mendiondo, Marta S.
AU - Matthews, Dwight E.
AU - Mitsumoto, Hiroshi
AU - Tandan, Rup
AU - Simmons, Zachary
AU - Kryscio, Richard J.
AU - Bromberg, Mark B.
N1 - Funding Information:
The University of Kentucky ’s multicenter nutrition study was funded by the National Institute of Neurological Disorders and Stroke, the ALS Hope Foundation, and the Cynthia Shaw Crispen Endowment. Research reported in this publication was additionally supported by the National Center for Advancing Translational Sciences of the National Institutes of Health.The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2015 Informa Healthcare.
PY - 2015/11/27
Y1 - 2015/11/27
N2 - Our objective was to explore if creatine kinase (CK) levels correlate with survival in amyotrophic lateral sclerosis (ALS), and whether a correlation is independent of other well-studied predictors such as location of onset, gender, age, fat free mass, spasticity, cramps, and fasciculations. We analyzed data from 80 ALS patients from a 48-week non-interventional longitudinal multicenter nutrition study with long term follow-up. The overall mean CK was 214 ± 191.8 U/l (range 22-1992 U/l). Forty-five percent of patients had at least one high CK value (> 200 U/l), and about half maintained a high CK value, but there was no trend over the study period. Male gender and extremity onset were significantly associated with high CK. In univariate analysis, age, bioelectric impedance spectroscopy (BIS) fat free mass, spasticity, and fasciculations were not associated with CK level. There was an association between CK and muscle cramps (p < 0.001). In survival analysis, low CK (≤ 200 U/l) was associated with a longer overall survival (p = 0.02), when adjusting for location of onset, age, race, gender, BIS fat free mass, and study site. In conclusion, CK may be a useful marker for ALS survival, which has implications for clinical care and the design of future clinical trials.
AB - Our objective was to explore if creatine kinase (CK) levels correlate with survival in amyotrophic lateral sclerosis (ALS), and whether a correlation is independent of other well-studied predictors such as location of onset, gender, age, fat free mass, spasticity, cramps, and fasciculations. We analyzed data from 80 ALS patients from a 48-week non-interventional longitudinal multicenter nutrition study with long term follow-up. The overall mean CK was 214 ± 191.8 U/l (range 22-1992 U/l). Forty-five percent of patients had at least one high CK value (> 200 U/l), and about half maintained a high CK value, but there was no trend over the study period. Male gender and extremity onset were significantly associated with high CK. In univariate analysis, age, bioelectric impedance spectroscopy (BIS) fat free mass, spasticity, and fasciculations were not associated with CK level. There was an association between CK and muscle cramps (p < 0.001). In survival analysis, low CK (≤ 200 U/l) was associated with a longer overall survival (p = 0.02), when adjusting for location of onset, age, race, gender, BIS fat free mass, and study site. In conclusion, CK may be a useful marker for ALS survival, which has implications for clinical care and the design of future clinical trials.
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U2 - 10.3109/21678421.2015.1062516
DO - 10.3109/21678421.2015.1062516
M3 - Article
C2 - 26312548
AN - SCOPUS:84947494117
VL - 16
SP - 473
EP - 477
JO - Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
JF - Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
SN - 2167-8421
IS - 7-8
ER -