Abstract
Our objective was to explore if creatine kinase (CK) levels correlate with survival in amyotrophic lateral sclerosis (ALS), and whether a correlation is independent of other well-studied predictors such as location of onset, gender, age, fat free mass, spasticity, cramps, and fasciculations. We analyzed data from 80 ALS patients from a 48-week non-interventional longitudinal multicenter nutrition study with long term follow-up. The overall mean CK was 214 ± 191.8 U/l (range 22-1992 U/l). Forty-five percent of patients had at least one high CK value (> 200 U/l), and about half maintained a high CK value, but there was no trend over the study period. Male gender and extremity onset were significantly associated with high CK. In univariate analysis, age, bioelectric impedance spectroscopy (BIS) fat free mass, spasticity, and fasciculations were not associated with CK level. There was an association between CK and muscle cramps (p < 0.001). In survival analysis, low CK (≤ 200 U/l) was associated with a longer overall survival (p = 0.02), when adjusting for location of onset, age, race, gender, BIS fat free mass, and study site. In conclusion, CK may be a useful marker for ALS survival, which has implications for clinical care and the design of future clinical trials.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 473-477 |
| Number of pages | 5 |
| Journal | Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration |
| Volume | 16 |
| Issue number | 7-8 |
| DOIs | |
| State | Published - Nov 27 2015 |
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All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
Cite this
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Relationship of creatine kinase to body composition, disease state, and longevity in ALS. / Gibson, Summer B.; Kasarskis, Edward J.; Hu, Nan; Pulst, Stefan M.; Mendiondo, Marta S.; Matthews, Dwight E.; Mitsumoto, Hiroshi; Tandan, Rup; Simmons, Zachary; Kryscio, Richard J.; Bromberg, Mark B.
In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Vol. 16, No. 7-8, 27.11.2015, p. 473-477.Research output: Contribution to journal › Article
TY - JOUR
T1 - Relationship of creatine kinase to body composition, disease state, and longevity in ALS
AU - Gibson, Summer B.
AU - Kasarskis, Edward J.
AU - Hu, Nan
AU - Pulst, Stefan M.
AU - Mendiondo, Marta S.
AU - Matthews, Dwight E.
AU - Mitsumoto, Hiroshi
AU - Tandan, Rup
AU - Simmons, Zachary
AU - Kryscio, Richard J.
AU - Bromberg, Mark B.
PY - 2015/11/27
Y1 - 2015/11/27
N2 - Our objective was to explore if creatine kinase (CK) levels correlate with survival in amyotrophic lateral sclerosis (ALS), and whether a correlation is independent of other well-studied predictors such as location of onset, gender, age, fat free mass, spasticity, cramps, and fasciculations. We analyzed data from 80 ALS patients from a 48-week non-interventional longitudinal multicenter nutrition study with long term follow-up. The overall mean CK was 214 ± 191.8 U/l (range 22-1992 U/l). Forty-five percent of patients had at least one high CK value (> 200 U/l), and about half maintained a high CK value, but there was no trend over the study period. Male gender and extremity onset were significantly associated with high CK. In univariate analysis, age, bioelectric impedance spectroscopy (BIS) fat free mass, spasticity, and fasciculations were not associated with CK level. There was an association between CK and muscle cramps (p < 0.001). In survival analysis, low CK (≤ 200 U/l) was associated with a longer overall survival (p = 0.02), when adjusting for location of onset, age, race, gender, BIS fat free mass, and study site. In conclusion, CK may be a useful marker for ALS survival, which has implications for clinical care and the design of future clinical trials.
AB - Our objective was to explore if creatine kinase (CK) levels correlate with survival in amyotrophic lateral sclerosis (ALS), and whether a correlation is independent of other well-studied predictors such as location of onset, gender, age, fat free mass, spasticity, cramps, and fasciculations. We analyzed data from 80 ALS patients from a 48-week non-interventional longitudinal multicenter nutrition study with long term follow-up. The overall mean CK was 214 ± 191.8 U/l (range 22-1992 U/l). Forty-five percent of patients had at least one high CK value (> 200 U/l), and about half maintained a high CK value, but there was no trend over the study period. Male gender and extremity onset were significantly associated with high CK. In univariate analysis, age, bioelectric impedance spectroscopy (BIS) fat free mass, spasticity, and fasciculations were not associated with CK level. There was an association between CK and muscle cramps (p < 0.001). In survival analysis, low CK (≤ 200 U/l) was associated with a longer overall survival (p = 0.02), when adjusting for location of onset, age, race, gender, BIS fat free mass, and study site. In conclusion, CK may be a useful marker for ALS survival, which has implications for clinical care and the design of future clinical trials.
UR - http://www.scopus.com/inward/record.url?scp=84947494117&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84947494117&partnerID=8YFLogxK
U2 - 10.3109/21678421.2015.1062516
DO - 10.3109/21678421.2015.1062516
M3 - Article
C2 - 26312548
AN - SCOPUS:84947494117
VL - 16
SP - 473
EP - 477
JO - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
JF - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
SN - 2167-8421
IS - 7-8
ER -