Relationship of UV exposure to prevalence of multiple sclerosis in England

S. V. Ramagopalan, A. E. Handel, G. Giovannoni, S. Rutherford Siegel, G. C. Ebers, G. Chaplin

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE:: To assess the potential relationship of ultraviolet B radiation (UVB) and Epstein-Barr virus (EBV) exposure in explaining the period prevalence of multiple sclerosis (MS) in England. Methods: English national Hospital Episode Statistics covering all admissions to National Health Service hospitals in England in the 7 years from 1998 to 2005 were used to obtain the period prevalences of MS and infectious mononucleosis (IM) in England. The United States National Aeronautics and Space Administration Ês data on UVB intensity for England from the Nimbus 7 satellite was collected. The relationships among the 3 variables (MS prevalence, IM prevalence, and UVB intensity) were investigated. Results: The regression of MS against UVB intensity for all seasons had an r of 0.61; when including the interaction of IM with seasonal UVB, the r rose to 0.72. Conclusions: UVB exposure and IM together can explain a substantial proportion of the variance of MS. The effect of UVB on generating vitamin D seems the most likely candidate for explaining its relationship with MS. There is a pressing need to investigate the role of vitamin D and EBV and how they might interact to influence MS risk to identify potential prevention strategies.

Original languageEnglish (US)
Pages (from-to)1410-1414
Number of pages5
JournalNeurology
Volume76
Issue number16
DOIs
StatePublished - Apr 19 2011

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England
Multiple Sclerosis
Infectious Mononucleosis
Radiation
Human Herpesvirus 4
Vitamin D
United States National Aeronautics and Space Administration
National Health Programs

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Ramagopalan, S. V., Handel, A. E., Giovannoni, G., Siegel, S. R., Ebers, G. C., & Chaplin, G. (2011). Relationship of UV exposure to prevalence of multiple sclerosis in England. Neurology, 76(16), 1410-1414. https://doi.org/10.1212/WNL.0b013e318216715e
Ramagopalan, S. V. ; Handel, A. E. ; Giovannoni, G. ; Siegel, S. Rutherford ; Ebers, G. C. ; Chaplin, G. / Relationship of UV exposure to prevalence of multiple sclerosis in England. In: Neurology. 2011 ; Vol. 76, No. 16. pp. 1410-1414.
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Ramagopalan, SV, Handel, AE, Giovannoni, G, Siegel, SR, Ebers, GC & Chaplin, G 2011, 'Relationship of UV exposure to prevalence of multiple sclerosis in England', Neurology, vol. 76, no. 16, pp. 1410-1414. https://doi.org/10.1212/WNL.0b013e318216715e

Relationship of UV exposure to prevalence of multiple sclerosis in England. / Ramagopalan, S. V.; Handel, A. E.; Giovannoni, G.; Siegel, S. Rutherford; Ebers, G. C.; Chaplin, G.

In: Neurology, Vol. 76, No. 16, 19.04.2011, p. 1410-1414.

Research output: Contribution to journalArticle

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AU - Chaplin, G.

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Ramagopalan SV, Handel AE, Giovannoni G, Siegel SR, Ebers GC, Chaplin G. Relationship of UV exposure to prevalence of multiple sclerosis in England. Neurology. 2011 Apr 19;76(16):1410-1414. https://doi.org/10.1212/WNL.0b013e318216715e