Relationships between serum and colon concentrations of carotenoids and fatty acids in randomized dietary intervention trial

Ananda Sen, Jianwei Ren, Mack Ruffin, Danielle K. Turgeon, Dean E. Brenner, Elkhansa Sidahmed, Mary E. Rapai, Maria L. Cornellier, Zora Djuric

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Little is known about the effect of preventive diets on colonic nutrient concentrations. This study randomized 120 persons at increased risk of colon cancer to a Mediterranean versus a Healthy Eating diet for six months. The former targeted increases in whole grains, fruits, vegetables, monounsaturated, and n3 fats. The Healthy Eating diet was based on Healthy People 2010 recommendations. At baseline, dietary fat and carotenoid intakes were poorly associated (Spearman ρ < 0.4) with serum and colon concentrations. Strong associations were observed between serum and colon measurements of β-cryptoxanthin (ρ = 0.58; P < 0.001), α-carotene (ρ = 0.48; P < 0.001), and β-carotene (ρ = 0.45; P < 0.001). After six months, the Healthy Eating intervention increased serum lutein, β-, and α-carotene significantly (P < 0.05). In the Mediterranean arm, the significant increases were in serum lutein, β-cryptoxanthin, β-carotene, monounsaturated, and n3 fats. A significant group-by-time interaction (P = 0.03) was obtained for monounsaturated fats. Colonic increases in carotenoids and n3 fats were significant only in Healthy Eating arm, whereas the group-by-time interaction was significant for β-carotene (P = 0.02) and α-carotene (P = 0.03). Changes in colon concentrations were not significantly associated with reported dietary changes. Changes in colon and serum concentrations were strongly associated for β-cryptoxanthin (ρ = 0.56; P < 0.001) and α-carotene (ρ = 0.40; P < 0.001). The associations between colonic and serum concentrations suggest the potential use of using serum concentration as a target in dietary interventions aimed at reducing colon cancer risk.

Original languageEnglish (US)
Pages (from-to)558-565
Number of pages8
JournalCancer Prevention Research
Volume6
Issue number6
DOIs
StatePublished - Jun 1 2013

Fingerprint

Carotenoids
Colon
Fatty Acids
Serum
Fats
Lutein
Colonic Neoplasms
Healthy People Programs
Dietary Fats
Vegetables
Healthy Diet
Fruit
Diet
Food

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Sen, Ananda ; Ren, Jianwei ; Ruffin, Mack ; Turgeon, Danielle K. ; Brenner, Dean E. ; Sidahmed, Elkhansa ; Rapai, Mary E. ; Cornellier, Maria L. ; Djuric, Zora. / Relationships between serum and colon concentrations of carotenoids and fatty acids in randomized dietary intervention trial. In: Cancer Prevention Research. 2013 ; Vol. 6, No. 6. pp. 558-565.
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Relationships between serum and colon concentrations of carotenoids and fatty acids in randomized dietary intervention trial. / Sen, Ananda; Ren, Jianwei; Ruffin, Mack; Turgeon, Danielle K.; Brenner, Dean E.; Sidahmed, Elkhansa; Rapai, Mary E.; Cornellier, Maria L.; Djuric, Zora.

In: Cancer Prevention Research, Vol. 6, No. 6, 01.06.2013, p. 558-565.

Research output: Contribution to journalArticle

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AU - Ren, Jianwei

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AU - Brenner, Dean E.

AU - Sidahmed, Elkhansa

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