Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York

Steven D. Stellman, Mirjana V. Djordjevic, Joshua Muscat, Lin Gong, David Bernstein, Marc L. Citron, Agnès White, Margaret Kemeny, Erna Busch, Anne N. Nafziger

Research output: Contribution to journalArticle

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Abstract

Some organochlorine pesticides (OCPs) and PCBs are under investigation as possible risk factors for breast cancer because of their estrogenic properties and widespread presence in the environment. It is important to know whether adipose tissue used by some investigators and serum assays used by others can provide comparable information on body burden. Concentrations of seven OCPs or their breakdown products as well as 14 PCB congeners were measured in the adipose tissue and serum of 293 women enrolled as controls in a case-control study of environmental factors for breast cancer in Long Island, New York, a high-risk region. Adipose OCP/PCB levels were measured using a supercritical fluid extraction method developed by the authors. 1,1- Dichloro-2,2-di(4-chlorophenyl)ethylene (p,p'-DDE) was detected in all adipose and serum samples; two chlordane derivatives, β- hexachlorocyclohexane (a lindane isomer) and hexachlorobenzene, were detected in at least 92% of adipose samples. The di-ortho hexachlorinated PCB congeners 2,4,5,2',4',5'-hexachlorobiphenyl and 2,3,4,2',4',5'- hexachlorobiphenyl were detected in all adipose and over 98% of serum samples. 1,1-Dichloro-2,2-di(4-chlorophenyl)ethylene comprised 77% of total pesticide residues in adipose and 71% in serum. 2,4,5,2',4',5'- Hexachlorobiphenyl comprised 24% of adipose and 21% of serum PCBs. The relative concentration patterns of the 14 PCB congeners were similar to those reported in other human studies and were also typical of patterns reported in environmental samples from various biota, including mammals and birds, but differed substantially from patterns reported in occupationally exposed workers. All adipose-serum correlations for pesticides and most PCBs were statistically significant. Either serum or adipose OCP/PCB levels of a variety of environmental organochlorine compounds may serve as useful biomarkers of body burden.

Original languageEnglish (US)
Pages (from-to)489-496
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume7
Issue number6
StatePublished - Jun 1 1998

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Polychlorinated Biphenyls
Pesticides
Islands
Adipose Tissue
2,4,5,2',4',5'-hexachlorobiphenyl
Serum
Body Burden
Lindane
Chlordan
Breast Neoplasms
Hexachlorobenzene
Supercritical Fluid Chromatography
Dichlorodiphenyl Dichloroethylene
Chlorinated Hydrocarbons
Pesticide Residues
Biota
Birds
Case-Control Studies
Mammals
Biomarkers

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Stellman, Steven D. ; Djordjevic, Mirjana V. ; Muscat, Joshua ; Gong, Lin ; Bernstein, David ; Citron, Marc L. ; White, Agnès ; Kemeny, Margaret ; Busch, Erna ; Nafziger, Anne N. / Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York. In: Cancer Epidemiology Biomarkers and Prevention. 1998 ; Vol. 7, No. 6. pp. 489-496.
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title = "Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York",
abstract = "Some organochlorine pesticides (OCPs) and PCBs are under investigation as possible risk factors for breast cancer because of their estrogenic properties and widespread presence in the environment. It is important to know whether adipose tissue used by some investigators and serum assays used by others can provide comparable information on body burden. Concentrations of seven OCPs or their breakdown products as well as 14 PCB congeners were measured in the adipose tissue and serum of 293 women enrolled as controls in a case-control study of environmental factors for breast cancer in Long Island, New York, a high-risk region. Adipose OCP/PCB levels were measured using a supercritical fluid extraction method developed by the authors. 1,1- Dichloro-2,2-di(4-chlorophenyl)ethylene (p,p'-DDE) was detected in all adipose and serum samples; two chlordane derivatives, β- hexachlorocyclohexane (a lindane isomer) and hexachlorobenzene, were detected in at least 92{\%} of adipose samples. The di-ortho hexachlorinated PCB congeners 2,4,5,2',4',5'-hexachlorobiphenyl and 2,3,4,2',4',5'- hexachlorobiphenyl were detected in all adipose and over 98{\%} of serum samples. 1,1-Dichloro-2,2-di(4-chlorophenyl)ethylene comprised 77{\%} of total pesticide residues in adipose and 71{\%} in serum. 2,4,5,2',4',5'- Hexachlorobiphenyl comprised 24{\%} of adipose and 21{\%} of serum PCBs. The relative concentration patterns of the 14 PCB congeners were similar to those reported in other human studies and were also typical of patterns reported in environmental samples from various biota, including mammals and birds, but differed substantially from patterns reported in occupationally exposed workers. All adipose-serum correlations for pesticides and most PCBs were statistically significant. Either serum or adipose OCP/PCB levels of a variety of environmental organochlorine compounds may serve as useful biomarkers of body burden.",
author = "Stellman, {Steven D.} and Djordjevic, {Mirjana V.} and Joshua Muscat and Lin Gong and David Bernstein and Citron, {Marc L.} and Agn{\`e}s White and Margaret Kemeny and Erna Busch and Nafziger, {Anne N.}",
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Stellman, SD, Djordjevic, MV, Muscat, J, Gong, L, Bernstein, D, Citron, ML, White, A, Kemeny, M, Busch, E & Nafziger, AN 1998, 'Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York', Cancer Epidemiology Biomarkers and Prevention, vol. 7, no. 6, pp. 489-496.

Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York. / Stellman, Steven D.; Djordjevic, Mirjana V.; Muscat, Joshua; Gong, Lin; Bernstein, David; Citron, Marc L.; White, Agnès; Kemeny, Margaret; Busch, Erna; Nafziger, Anne N.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 7, No. 6, 01.06.1998, p. 489-496.

Research output: Contribution to journalArticle

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AU - Stellman, Steven D.

AU - Djordjevic, Mirjana V.

AU - Muscat, Joshua

AU - Gong, Lin

AU - Bernstein, David

AU - Citron, Marc L.

AU - White, Agnès

AU - Kemeny, Margaret

AU - Busch, Erna

AU - Nafziger, Anne N.

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