Relative contributions of the membrane and hemoglobin to sickle cell deformability

Cheng Dong, Richard S. Chadwick

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A continuum mechanics model of sickled red blood cells in a narrow capillary is developed based on the viscometric studies of polymerized sickled hemoglobin solutions by Chien et al. (1982). That study as well as other published experimental data have suggested the rheology of a sickled red blood can be represented by a Voigt solid bounded by an elastic membrane. Here the relative contributions of the red cell membrane and intracellular hemoglobin solution (with or without polymer) to the overall sickle cell deformability is studied. The model describes how the amount of polymer inside a sickle erythrocyte changes its elasticity and viscosity and therefore influences the deformability and flow resistance of the cell at different oxygen (O2) saturation levels.

Original languageEnglish (US)
Title of host publication1991 Advances in Bioengineering
PublisherPubl by ASME
Pages85-88
Number of pages4
ISBN (Print)0791808890
StatePublished - Dec 1 1991
EventWinter Annual Meeting of the American Society of Mechanical Engineers - Atlanta, GA, USA
Duration: Dec 1 1991Dec 6 1991

Publication series

NameAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Volume20

Other

OtherWinter Annual Meeting of the American Society of Mechanical Engineers
CityAtlanta, GA, USA
Period12/1/9112/6/91

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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  • Cite this

    Dong, C., & Chadwick, R. S. (1991). Relative contributions of the membrane and hemoglobin to sickle cell deformability. In 1991 Advances in Bioengineering (pp. 85-88). (American Society of Mechanical Engineers, Bioengineering Division (Publication) BED; Vol. 20). Publ by ASME.