Release of gonadotrophin-releasing hormone (Gn-Rh) from isolated, perifused medial-basal hypothalamus by melatonin

Lidia Wei Liu Kao, Judith Weisz

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Basal release of Gn-RH from perifused medial-basal hypothalami of rats was at or below levels detectable by radioimmunoassay. Infusion of norepinephrine, dopamine, acetylcholine or serotonin (0.1–10 mM) as 10–20 min pulses was not associated with a detectable increase of Gn-RH in the effluent. However, 10–20 min pulses of melatonin (0.1–1.0 mM) consistently caused release of Gn-RH.

Original languageEnglish (US)
Pages (from-to)1723-1726
Number of pages4
JournalEndocrinology
Volume100
Issue number6
DOIs
StatePublished - Jun 1977

All Science Journal Classification (ASJC) codes

  • Endocrinology

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