Release of gonadotrophin-releasing hormone (Gn-Rh) from isolated, perifused medial-basal hypothalamus by melatonin

Lidia Wei Liu Kao; Judith Weisz

doi:10.1210/endo-100-6-1723

Release of gonadotrophin-releasing hormone (Gn-Rh) from isolated, perifused medial-basal hypothalamus by melatonin

Lidia Wei Liu Kao, Judith Weisz

Department of Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Basal release of Gn-RH from perifused medial-basal hypothalami of rats was at or below levels detectable by radioimmunoassay. Infusion of norepinephrine, dopamine, acetylcholine or serotonin (0.1–10 mM) as 10–20 min pulses was not associated with a detectable increase of Gn-RH in the effluent. However, 10–20 min pulses of melatonin (0.1–1.0 mM) consistently caused release of Gn-RH.

Original language	English (US)
Pages (from-to)	1723-1726
Number of pages	4
Journal	Endocrinology
Volume	100
Issue number	6
DOIs	https://doi.org/10.1210/endo-100-6-1723
State	Published - Jun 1977

All Science Journal Classification (ASJC) codes

Endocrinology

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10.1210/endo-100-6-1723

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title = "Release of gonadotrophin-releasing hormone (Gn-Rh) from isolated, perifused medial-basal hypothalamus by melatonin",

abstract = "Basal release of Gn-RH from perifused medial-basal hypothalami of rats was at or below levels detectable by radioimmunoassay. Infusion of norepinephrine, dopamine, acetylcholine or serotonin (0.1–10 mM) as 10–20 min pulses was not associated with a detectable increase of Gn-RH in the effluent. However, 10–20 min pulses of melatonin (0.1–1.0 mM) consistently caused release of Gn-RH.",

author = "Kao, {Lidia Wei Liu} and Judith Weisz",

year = "1977",

month = jun,

doi = "10.1210/endo-100-6-1723",

language = "English (US)",

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journal = "Endocrinology",

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AU - Kao, Lidia Wei Liu

AU - Weisz, Judith

PY - 1977/6

Y1 - 1977/6

N2 - Basal release of Gn-RH from perifused medial-basal hypothalami of rats was at or below levels detectable by radioimmunoassay. Infusion of norepinephrine, dopamine, acetylcholine or serotonin (0.1–10 mM) as 10–20 min pulses was not associated with a detectable increase of Gn-RH in the effluent. However, 10–20 min pulses of melatonin (0.1–1.0 mM) consistently caused release of Gn-RH.

AB - Basal release of Gn-RH from perifused medial-basal hypothalami of rats was at or below levels detectable by radioimmunoassay. Infusion of norepinephrine, dopamine, acetylcholine or serotonin (0.1–10 mM) as 10–20 min pulses was not associated with a detectable increase of Gn-RH in the effluent. However, 10–20 min pulses of melatonin (0.1–1.0 mM) consistently caused release of Gn-RH.

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Release of gonadotrophin-releasing hormone (Gn-Rh) from isolated, perifused medial-basal hypothalamus by melatonin

Abstract

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