REM sleep behavior disorder was associated with Parkinson's disease: A community-based study

Jian Fang Ma, Miao Miao Hou, Hui Dong Tang, Xiang Gao, Liang Liang, Li Fang Zhu, Yi Zhou, Sheng Yu Zha, Shi Shuang Cui, Juan Juan Du, Gen Li, Jun Liu, Sheng Di Chen

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Background: Our study was aimed to validate a modified RBD (REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD (pRBD) in a rural community based on RBD1Q-C and investigate the association between pRBD and Parkinson's disease (PD). Methods: The validation study of RBD1Q-C included 32 Chinese participants (14 idiopathic RBD patients and 18 controls). All participants underwent a polysomnogram (PSG). We then conducted a door-to-door survey to estimate the prevalence of pRBD assessed by RBD1Q-C, and its association with PD among 19614 residents who lived in Malu community of Shanghai, China. Results: RBD1Q-C demonstrated a high sensitivity of 100 %, a moderate specificity of 55.6 %. The agreement between RBD1Q-C and PSG-based RBD diagnosis was good (k=0.552). PPV of the RBD1Q-C was 63.6 % and NPV was 100 %. The prevalence of pRBD in Malu community was 4.9 %. In people over 50 years old, presence of pRBD was significantly associated with increased risk of having PD (odds ratio=2.61, 95 % CI: 1.56-4.39). Conclusion: RBD1Q-C was shown to be a useful screening tool. Based on the RBD1Q-C, we found that pRBD was not rare in Chinese rural population and associated with odds of PD, calling for more attention from patients, caregivers and physicians.

Original languageEnglish (US)
Article number123
JournalBMC Neurology
Issue number1
StatePublished - Aug 2 2016

All Science Journal Classification (ASJC) codes

  • Clinical Neurology


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