Renal denervation decreases blood pressure in doca-treated miniature swine with established hypertension

Kathleen P. O‘Hagan, Gail D. Thomas, Edward J. Zambraski

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The role of renal sympathetic nerve activity (RSNA) in the maintenance phase of essential hypertension has not yet been clearly defined. Renal function and mean arterial pressure (MAP) were studied in four Yucatan miniature swine (YMS) with established DOCA hypertension prior to and for 3 weeks after surgical renal denervation (RDX). During the first week post-RDX, MAP decreased from 141 ± 6 to 121 ± 3 mm Hg (P <. 05), while sodium balance increased from 0.32 ± 0.05 to 0.95 ± 0.14 mEq/kg/day (P <. 05). By 3 weeks post-RDX, MAP remained below normotensive levels while sodium balance returned to the pre-RDX value. There was no significant change in potassium or water balance after RDX. Thus, in DOCA-YMS the renal nerves are important in the maintenance of hypertension. The reduction in MAP with RDX in the absence of a natriuresis suggests a role for renal afferent nerve activity.

Original languageEnglish (US)
Pages (from-to)62-64
Number of pages3
JournalAmerican journal of hypertension
Volume3
Issue number1
DOIs
StatePublished - Jan 1990

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Fingerprint

Dive into the research topics of 'Renal denervation decreases blood pressure in doca-treated miniature swine with established hypertension'. Together they form a unique fingerprint.

Cite this