Renal function and isomers of perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS)

Isomers of C8 Health Project in China

Jia Wang, Xiao Wen Zeng, Michael S. Bloom, Zhengmin Qian, Leslie J. Hinyard, Rhonda Belue, Shao Lin, Si Quan Wang, Yan Peng Tian, Mo Yang, Chu Chu, Namratha Gurram, Li Wen Hu, Kang Kang Liu, Bo Yi Yang, Dan Feng, Ru Qing Liu, Guang Hui Dong

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Perfluoroalkyl substances (PFASs) are widely-utilized synthetic chemicals commonly found in industrial and consumer products. Previous studies have examined associations between PFASs and renal function, yet the results are mixed. Moreover, evidence on the associations of isomers of PFASs with renal function in population from high polluted areas is scant. To help to address this data gap, we used high performance liquid chromatography-mass spectrometry to measure serum isomers of perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), and other PFASs from 1612 adults residing in Shenyang, China, and characterized their associations with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD). Results showed that after adjusted for multiple confounding factors, most of the higher fluorinated PFASs, except for PFOA and PFDA, were negatively associated with eGFR and positively associated with CKD. Compared with linear PFOS (n-PFOS), branched PFOS isomers (Br-PFOS) were more strongly associated with eGFR (Br-PFOS; β = −1.22, 95%CI: 2.02, −0.42; p = 0.003 vs. n-PFOS; β = −0.16, 95%CI: 0.98, 0.65; p = 0.691) and CKD (Br-PFOS; OR = 1.27; 95% CI: 1.02, 1.58; p = 0.037 vs. n-PFOS; OR = 0.98; 95% CI: 0.80, 1.20; p = 0.834). In conclusion, branched PFOS isomers were negatively associated with renal function whereas their linear counterparts were not. Given widespread exposure to PFASs, potential nephrotoxic effects are of great public health concern, Furthermore, longitudinal research on the potential nephrotoxic effects of PFASs isomers will be necessary to more definitively assess the risk.

Original languageEnglish (US)
Pages (from-to)1042-1049
Number of pages8
JournalChemosphere
DOIs
StatePublished - Mar 1 2019

Fingerprint

perfluorooctanoic acid
Isomers
China
Health
Kidney
Glomerular Filtration Rate
Chronic Renal Insufficiency
Consumer products
High performance liquid chromatography
Public health
perfluorooctane sulfonic acid
isomer
health
project
Mass spectrometry
public health
liquid chromatography
serum

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Wang, Jia ; Zeng, Xiao Wen ; Bloom, Michael S. ; Qian, Zhengmin ; Hinyard, Leslie J. ; Belue, Rhonda ; Lin, Shao ; Wang, Si Quan ; Tian, Yan Peng ; Yang, Mo ; Chu, Chu ; Gurram, Namratha ; Hu, Li Wen ; Liu, Kang Kang ; Yang, Bo Yi ; Feng, Dan ; Liu, Ru Qing ; Dong, Guang Hui. / Renal function and isomers of perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) : Isomers of C8 Health Project in China. In: Chemosphere. 2019 ; pp. 1042-1049.
@article{a30b363992e34903af5e548713320dae,
title = "Renal function and isomers of perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS): Isomers of C8 Health Project in China",
abstract = "Perfluoroalkyl substances (PFASs) are widely-utilized synthetic chemicals commonly found in industrial and consumer products. Previous studies have examined associations between PFASs and renal function, yet the results are mixed. Moreover, evidence on the associations of isomers of PFASs with renal function in population from high polluted areas is scant. To help to address this data gap, we used high performance liquid chromatography-mass spectrometry to measure serum isomers of perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), and other PFASs from 1612 adults residing in Shenyang, China, and characterized their associations with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD). Results showed that after adjusted for multiple confounding factors, most of the higher fluorinated PFASs, except for PFOA and PFDA, were negatively associated with eGFR and positively associated with CKD. Compared with linear PFOS (n-PFOS), branched PFOS isomers (Br-PFOS) were more strongly associated with eGFR (Br-PFOS; β = −1.22, 95{\%}CI: 2.02, −0.42; p = 0.003 vs. n-PFOS; β = −0.16, 95{\%}CI: 0.98, 0.65; p = 0.691) and CKD (Br-PFOS; OR = 1.27; 95{\%} CI: 1.02, 1.58; p = 0.037 vs. n-PFOS; OR = 0.98; 95{\%} CI: 0.80, 1.20; p = 0.834). In conclusion, branched PFOS isomers were negatively associated with renal function whereas their linear counterparts were not. Given widespread exposure to PFASs, potential nephrotoxic effects are of great public health concern, Furthermore, longitudinal research on the potential nephrotoxic effects of PFASs isomers will be necessary to more definitively assess the risk.",
author = "Jia Wang and Zeng, {Xiao Wen} and Bloom, {Michael S.} and Zhengmin Qian and Hinyard, {Leslie J.} and Rhonda Belue and Shao Lin and Wang, {Si Quan} and Tian, {Yan Peng} and Mo Yang and Chu Chu and Namratha Gurram and Hu, {Li Wen} and Liu, {Kang Kang} and Yang, {Bo Yi} and Dan Feng and Liu, {Ru Qing} and Dong, {Guang Hui}",
year = "2019",
month = "3",
day = "1",
doi = "10.1016/j.chemosphere.2018.11.191",
language = "English (US)",
pages = "1042--1049",
journal = "Chemosphere",
issn = "0045-6535",
publisher = "Elsevier Limited",

}

Wang, J, Zeng, XW, Bloom, MS, Qian, Z, Hinyard, LJ, Belue, R, Lin, S, Wang, SQ, Tian, YP, Yang, M, Chu, C, Gurram, N, Hu, LW, Liu, KK, Yang, BY, Feng, D, Liu, RQ & Dong, GH 2019, 'Renal function and isomers of perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS): Isomers of C8 Health Project in China', Chemosphere, pp. 1042-1049. https://doi.org/10.1016/j.chemosphere.2018.11.191

Renal function and isomers of perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) : Isomers of C8 Health Project in China. / Wang, Jia; Zeng, Xiao Wen; Bloom, Michael S.; Qian, Zhengmin; Hinyard, Leslie J.; Belue, Rhonda; Lin, Shao; Wang, Si Quan; Tian, Yan Peng; Yang, Mo; Chu, Chu; Gurram, Namratha; Hu, Li Wen; Liu, Kang Kang; Yang, Bo Yi; Feng, Dan; Liu, Ru Qing; Dong, Guang Hui.

In: Chemosphere, 01.03.2019, p. 1042-1049.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Renal function and isomers of perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS)

T2 - Isomers of C8 Health Project in China

AU - Wang, Jia

AU - Zeng, Xiao Wen

AU - Bloom, Michael S.

AU - Qian, Zhengmin

AU - Hinyard, Leslie J.

AU - Belue, Rhonda

AU - Lin, Shao

AU - Wang, Si Quan

AU - Tian, Yan Peng

AU - Yang, Mo

AU - Chu, Chu

AU - Gurram, Namratha

AU - Hu, Li Wen

AU - Liu, Kang Kang

AU - Yang, Bo Yi

AU - Feng, Dan

AU - Liu, Ru Qing

AU - Dong, Guang Hui

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Perfluoroalkyl substances (PFASs) are widely-utilized synthetic chemicals commonly found in industrial and consumer products. Previous studies have examined associations between PFASs and renal function, yet the results are mixed. Moreover, evidence on the associations of isomers of PFASs with renal function in population from high polluted areas is scant. To help to address this data gap, we used high performance liquid chromatography-mass spectrometry to measure serum isomers of perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), and other PFASs from 1612 adults residing in Shenyang, China, and characterized their associations with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD). Results showed that after adjusted for multiple confounding factors, most of the higher fluorinated PFASs, except for PFOA and PFDA, were negatively associated with eGFR and positively associated with CKD. Compared with linear PFOS (n-PFOS), branched PFOS isomers (Br-PFOS) were more strongly associated with eGFR (Br-PFOS; β = −1.22, 95%CI: 2.02, −0.42; p = 0.003 vs. n-PFOS; β = −0.16, 95%CI: 0.98, 0.65; p = 0.691) and CKD (Br-PFOS; OR = 1.27; 95% CI: 1.02, 1.58; p = 0.037 vs. n-PFOS; OR = 0.98; 95% CI: 0.80, 1.20; p = 0.834). In conclusion, branched PFOS isomers were negatively associated with renal function whereas their linear counterparts were not. Given widespread exposure to PFASs, potential nephrotoxic effects are of great public health concern, Furthermore, longitudinal research on the potential nephrotoxic effects of PFASs isomers will be necessary to more definitively assess the risk.

AB - Perfluoroalkyl substances (PFASs) are widely-utilized synthetic chemicals commonly found in industrial and consumer products. Previous studies have examined associations between PFASs and renal function, yet the results are mixed. Moreover, evidence on the associations of isomers of PFASs with renal function in population from high polluted areas is scant. To help to address this data gap, we used high performance liquid chromatography-mass spectrometry to measure serum isomers of perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), and other PFASs from 1612 adults residing in Shenyang, China, and characterized their associations with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD). Results showed that after adjusted for multiple confounding factors, most of the higher fluorinated PFASs, except for PFOA and PFDA, were negatively associated with eGFR and positively associated with CKD. Compared with linear PFOS (n-PFOS), branched PFOS isomers (Br-PFOS) were more strongly associated with eGFR (Br-PFOS; β = −1.22, 95%CI: 2.02, −0.42; p = 0.003 vs. n-PFOS; β = −0.16, 95%CI: 0.98, 0.65; p = 0.691) and CKD (Br-PFOS; OR = 1.27; 95% CI: 1.02, 1.58; p = 0.037 vs. n-PFOS; OR = 0.98; 95% CI: 0.80, 1.20; p = 0.834). In conclusion, branched PFOS isomers were negatively associated with renal function whereas their linear counterparts were not. Given widespread exposure to PFASs, potential nephrotoxic effects are of great public health concern, Furthermore, longitudinal research on the potential nephrotoxic effects of PFASs isomers will be necessary to more definitively assess the risk.

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U2 - 10.1016/j.chemosphere.2018.11.191

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