Renal function and oncologic outcomes of parenchymal sparing ureteral resection versus radical nephroureterectomy for upper tract urothelial carcinoma

Jonathan L. Silberstein, Nicholas E. Power, Caroline Savage, Tatum V. Tarin, Ricardo L. Favaretto, Daniel Su, Matthew G. Kaag, Harry W. Herr, Guido Dalbagni

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We compared renal function and oncologic outcomes of parenchymal sparing ureteral resection with radical nephroureterectomy for the treatment of upper tract urothelial carcinoma confined to the ureter. Review of a large institutional database identified 367 patients treated for primary upper tract urothelial carcinoma with radical nephroureterectomy or parenchymal sparing ureteral resection from 1994 to 2009. Patients with known renal pelvis tumors, muscle invasive urothelial carcinoma, prior cystectomy, contralateral upper tract urothelial carcinoma, metastatic disease or chemotherapy were excluded, leaving 120 patients for analysis. Estimated glomerular filtration rate was calculated using the Modification of Diet in Renal Disease equation. Recurrence-free, cancer specific and overall survival were estimated using Kaplan-Meier analysis. Radical nephroureterectomy was performed in 87 patients and parenchymal sparing ureteral resection in 33. Median age at surgery was 73 years in the radical nephroureterectomy group (IQR 6476) vs 70 years (IQR 5977) in the parenchymal sparing ureteral resection group (p = 0.5). The radical nephroureterectomy and parenchymal sparing ureteral resection cohorts had several disparate clinicopathological variables including preoperative hydronephrosis (80% vs 45%, p = 0.0006), stage (pT3 or greater 26% vs 9%, p = 0.01) and baseline estimated glomerular filtration rate (51 vs 63 ml/minute/1.73 m 2, p = 0.009). Patients who underwent radical nephroureterectomy experienced a significantly greater decrease in estimated glomerular filtration rate after surgery (median -7 vs 0 ml/minute/1.73 m 2, p <0.001). Median followup was 4.2 years. Of the patients 79 experienced cancer recurrence and 44 died (28 of upper tract urothelial carcinoma). There were no obvious differences in the rates of recurrence, cancer specific death or overall death by procedure type. However, due to the limited number of events we cannot exclude the possibility that there are large differences in oncologic outcomes by procedure type. Parenchymal sparing ureteral resection is associated with superior postoperative renal function. However, the impact on cancer control cannot be determined conclusively due to the small sample size and putative selection bias.

Original languageEnglish (US)
Pages (from-to)429-434
Number of pages6
JournalJournal of Urology
Volume187
Issue number2
DOIs
StatePublished - Feb 1 2012

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Carcinoma
Kidney
Glomerular Filtration Rate
Neoplasms
Recurrence
Diet Therapy
Kidney Pelvis
Selection Bias
Hydronephrosis
Cystectomy
Kaplan-Meier Estimate
Ureter
Sample Size
Databases
Drug Therapy
Muscles
Survival
Therapeutics

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Silberstein, Jonathan L. ; Power, Nicholas E. ; Savage, Caroline ; Tarin, Tatum V. ; Favaretto, Ricardo L. ; Su, Daniel ; Kaag, Matthew G. ; Herr, Harry W. ; Dalbagni, Guido. / Renal function and oncologic outcomes of parenchymal sparing ureteral resection versus radical nephroureterectomy for upper tract urothelial carcinoma. In: Journal of Urology. 2012 ; Vol. 187, No. 2. pp. 429-434.
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Renal function and oncologic outcomes of parenchymal sparing ureteral resection versus radical nephroureterectomy for upper tract urothelial carcinoma. / Silberstein, Jonathan L.; Power, Nicholas E.; Savage, Caroline; Tarin, Tatum V.; Favaretto, Ricardo L.; Su, Daniel; Kaag, Matthew G.; Herr, Harry W.; Dalbagni, Guido.

In: Journal of Urology, Vol. 187, No. 2, 01.02.2012, p. 429-434.

Research output: Contribution to journalArticle

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T1 - Renal function and oncologic outcomes of parenchymal sparing ureteral resection versus radical nephroureterectomy for upper tract urothelial carcinoma

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