Renal histamine increases in the streptozotocin-diabetic rat

Ronald Albert Markle, Theodore M. Hollis, Andrew J. Cosgarea

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Renal histamine concentration, total histamine and protein contents were measured in rats made diabetic via iv streptozotocin injection and held for 13 weeks following diagnosis of diabetes. Insulin (7 U/day) or α-hydrazinohistidine (α-HH, 25 mg/kg/day) or both drugs were administered todiabetic subgroups the last 2 weeks of the holding period. Untreated diabetics developed significant increases of renal histamine concentration and total histamine content, up 45 and 46%, respectively. Drug interventions reduced the diabetic increases of histamine concentration and content (in order) as follows: diabetic-insulin, down 7 and 8%; diabetic-α-HH down 25 and 26%; diabetic-insulin + α-HH, down 35 and 36%. Renal tissue proteincontent was unchanged and qualitative proteinuria was present in all diabetic subgroups. The data indicate that in experimental diabetes there is an increase of the renal inducible histamine pool which is partially reduced by insulin and/or α-HH treatments. In view of the long-recognized actions of histamine upon microvascular permeability, elevated renal histamine may be one pathophysiological mediator of the diabetic functional renal microangiopathy manifest as proteinuria.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalExperimental and Molecular Pathology
Volume44
Issue number1
DOIs
StatePublished - Jan 1 1986

Fingerprint

Streptozocin
Histamine
Rats
Kidney
Insulin
Medical problems
Proteinuria
Capillary Permeability
Pharmaceutical Preparations
Tissue
Injections

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

Markle, Ronald Albert ; Hollis, Theodore M. ; Cosgarea, Andrew J. / Renal histamine increases in the streptozotocin-diabetic rat. In: Experimental and Molecular Pathology. 1986 ; Vol. 44, No. 1. pp. 21-28.
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Renal histamine increases in the streptozotocin-diabetic rat. / Markle, Ronald Albert; Hollis, Theodore M.; Cosgarea, Andrew J.

In: Experimental and Molecular Pathology, Vol. 44, No. 1, 01.01.1986, p. 21-28.

Research output: Contribution to journalArticle

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