Renal vascular responses to static handgrip: Role of muscle mechanoreflex

Afsana Momen, Urs A. Leuenberger, Chester A. Ray, Susan Cha, Brian Handly, Lawrence I. Sinoway

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

During exercise, the sympathetic nervous system is activated, which causes vasoconstriction. The autonomic mechanisms responsible for this vasoconstriction vary based on the particular tissue being studied. Attempts to examine reflex control of the human renal circulation have been difficult because of technical limitations. In this report, the Doppler technique was used to examine renal flow velocity during four muscle contraction paradigms in conscious humans. Flow velocity was divided by mean arterial blood pressure to yield an index of renal vascular resistance (RVR). Fatiguing static handgrip (40% of maximal voluntary contraction) increased RVR by 76%. During posthandgrip circulatory arrest, RVR remained above baseline (2.1 ± 0.2 vs. 2.8 ± 0.2 arbitrary units; P < 0.017) but was only 40% of the end-grip RVR value. Voluntary biceps contraction increased RVR within 10 s of initiation of contraction. This effect was not associated with an increase in blood pressure. Finally, involuntary biceps contraction also raised RVR. We conclude that muscle contraction evokes renal vasoconstriction in conscious humans. The characteristic of this response is consistent with a primary role for mechanically sensitive afferents. This statement is based on the small posthandgrip circulatory arrest response and the vasoconstriction that was observed with involuntary biceps contraction.

Original languageEnglish (US)
Pages (from-to)H1247-H1253
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume285
Issue number3 54-3
StatePublished - Sep 1 2003

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Blood Vessels
Vascular Resistance
Kidney
Muscles
Vasoconstriction
Muscle Contraction
Arterial Pressure
Renal Circulation
Sympathetic Nervous System
Hand Strength
Reflex
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

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abstract = "During exercise, the sympathetic nervous system is activated, which causes vasoconstriction. The autonomic mechanisms responsible for this vasoconstriction vary based on the particular tissue being studied. Attempts to examine reflex control of the human renal circulation have been difficult because of technical limitations. In this report, the Doppler technique was used to examine renal flow velocity during four muscle contraction paradigms in conscious humans. Flow velocity was divided by mean arterial blood pressure to yield an index of renal vascular resistance (RVR). Fatiguing static handgrip (40{\%} of maximal voluntary contraction) increased RVR by 76{\%}. During posthandgrip circulatory arrest, RVR remained above baseline (2.1 ± 0.2 vs. 2.8 ± 0.2 arbitrary units; P < 0.017) but was only 40{\%} of the end-grip RVR value. Voluntary biceps contraction increased RVR within 10 s of initiation of contraction. This effect was not associated with an increase in blood pressure. Finally, involuntary biceps contraction also raised RVR. We conclude that muscle contraction evokes renal vasoconstriction in conscious humans. The characteristic of this response is consistent with a primary role for mechanically sensitive afferents. This statement is based on the small posthandgrip circulatory arrest response and the vasoconstriction that was observed with involuntary biceps contraction.",
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Renal vascular responses to static handgrip : Role of muscle mechanoreflex. / Momen, Afsana; Leuenberger, Urs A.; Ray, Chester A.; Cha, Susan; Handly, Brian; Sinoway, Lawrence I.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 285, No. 3 54-3, 01.09.2003, p. H1247-H1253.

Research output: Contribution to journalArticle

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