Repeated ethanol administration modifies the temporal structure of sucrose intake patterns in mice: Effects associated with behavioral sensitization

Raúl Pastor, Helen Marie Kamens, Carrie S. McKinnon, Matthew M. Ford, Tamara J. Phillips

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    Neuroadaptations supporting behavioral sensitization to abused drugs are suggested to underlie pathological, excessive motivation toward drugs and drug-associated stimuli. Drug-induced sensitization has also been linked to increased appetitive responses for non-drug, natural reinforcers. The present research investigated whether ethanol (EtOH)-induced neural changes, inferred from psychomotor sensitization, can modify consumption and intake dynamics for the natural reinforcer, sucrose. The effects of EtOH-induced sensitization in mice on the temporal structure of sucrose intake patterns were measured using a lickometer system. After sensitization, sucrose intake dynamics were measured for 1 hour daily for 7 days and indicated more rapid initial approach and consumption of sucrose in EtOH-sensitized groups; animals showed a shorter latency to the first intake bout and an increased number of sucrose bottle licks during the initial 15 minutes of the 1-hour sessions. This effect was associated with increased frequency and size of bouts. For the total 1-hour session, sucrose intake and bout dynamics were not different between groups, indicating a change in patterns of sucrose intake but not total consumption. When sensitization was prevented by the γ-aminobutyric acid B receptor agonist, baclofen, the increased rate of approach and consumption of sucrose were also prevented. Thus, EtOH-induced sensitization, and not the mere exposure to EtOH, was associated with changes in sucrose intake patterns. These data are consistent with current literature suggesting an enhancing effect of drug-induced sensitization on motivational processes involved in reinforcement.

    Original languageEnglish (US)
    Pages (from-to)324-335
    Number of pages12
    JournalAddiction Biology
    Volume15
    Issue number3
    DOIs
    StatePublished - Jan 1 2010

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    Sucrose
    Ethanol
    Pharmaceutical Preparations
    GABA-B Receptors
    Aminobutyrates
    Research

    All Science Journal Classification (ASJC) codes

    • Medicine (miscellaneous)
    • Pharmacology
    • Psychiatry and Mental health

    Cite this

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    abstract = "Neuroadaptations supporting behavioral sensitization to abused drugs are suggested to underlie pathological, excessive motivation toward drugs and drug-associated stimuli. Drug-induced sensitization has also been linked to increased appetitive responses for non-drug, natural reinforcers. The present research investigated whether ethanol (EtOH)-induced neural changes, inferred from psychomotor sensitization, can modify consumption and intake dynamics for the natural reinforcer, sucrose. The effects of EtOH-induced sensitization in mice on the temporal structure of sucrose intake patterns were measured using a lickometer system. After sensitization, sucrose intake dynamics were measured for 1 hour daily for 7 days and indicated more rapid initial approach and consumption of sucrose in EtOH-sensitized groups; animals showed a shorter latency to the first intake bout and an increased number of sucrose bottle licks during the initial 15 minutes of the 1-hour sessions. This effect was associated with increased frequency and size of bouts. For the total 1-hour session, sucrose intake and bout dynamics were not different between groups, indicating a change in patterns of sucrose intake but not total consumption. When sensitization was prevented by the γ-aminobutyric acid B receptor agonist, baclofen, the increased rate of approach and consumption of sucrose were also prevented. Thus, EtOH-induced sensitization, and not the mere exposure to EtOH, was associated with changes in sucrose intake patterns. These data are consistent with current literature suggesting an enhancing effect of drug-induced sensitization on motivational processes involved in reinforcement.",
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    Repeated ethanol administration modifies the temporal structure of sucrose intake patterns in mice : Effects associated with behavioral sensitization. / Pastor, Raúl; Kamens, Helen Marie; McKinnon, Carrie S.; Ford, Matthew M.; Phillips, Tamara J.

    In: Addiction Biology, Vol. 15, No. 3, 01.01.2010, p. 324-335.

    Research output: Contribution to journalArticle

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    AU - Pastor, Raúl

    AU - Kamens, Helen Marie

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    AU - Ford, Matthew M.

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