Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility

Irina Voineagu, Christine F. Surka, Alexander A. Shishkin, Maria M. Krasilnikova, Sergei M. Mirkin

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Expanded CGG repeats cause chromosomal fragility and hereditary neurological disorders in humans. Replication forks stall at CGG repeats in a length-dependent manner in primate cells and in yeast. Saccharomyces cerevisiae proteins Tof1 and Mrc1 facilitate replication fork progression through CGG repeats. Remarkably, the fork-stabilizing role of Mrc1 does not involve its checkpoint function. Thus, chromosomal fragility might occur when forks stalled at expanded CGG repeats escape the S-phase checkpoint.

Original languageEnglish (US)
Pages (from-to)226-228
Number of pages3
JournalNature Structural and Molecular Biology
Volume16
Issue number2
DOIs
StatePublished - Feb 1 2009

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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