Representation of response alternatives in human presupplementary motor area: Multi-voxel pattern analysis in a go/no-go task

John R. Fedota, Jillian E. Hardee, Koraly Pérez-Edgar, James C. Thompson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A debate exists as to the role of the presupplementary motor area (preSMA) in cognitive control. Recent findings suggest that preSMA plays a central role in conflict resolution and encodes response alternatives as opposed to simply the presence of conflict. Evidence of neuronal heterogeneity within preSMA of non-human primates suggests that univariate analysis of functional MRI data may not provide adequate resolution to fully characterize cognitive control-related responses. Here, multi-voxel pattern analysis (MVPA) is employed to examine the distributed patterns of activity in preSMA associated with both successful go responses and no-go inhibitions. In a go/no-go task, univariate analysis showed undifferentiated activation of preSMA in response to both go and no-go stimuli. However, when an anatomically-defined preSMA ROI was subjected to MVPA, a significant difference in the activation pattern encoded by go as compared to no-go stimuli was observed. These differences in preSMA activation are consistent with the ongoing maintenance and manipulation of stimulus-action representations.

Original languageEnglish (US)
Pages (from-to)110-118
Number of pages9
JournalNeuropsychologia
Volume56
Issue number1
DOIs
StatePublished - Apr 1 2014

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Motor Cortex
Negotiating
Primates
Maintenance
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

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abstract = "A debate exists as to the role of the presupplementary motor area (preSMA) in cognitive control. Recent findings suggest that preSMA plays a central role in conflict resolution and encodes response alternatives as opposed to simply the presence of conflict. Evidence of neuronal heterogeneity within preSMA of non-human primates suggests that univariate analysis of functional MRI data may not provide adequate resolution to fully characterize cognitive control-related responses. Here, multi-voxel pattern analysis (MVPA) is employed to examine the distributed patterns of activity in preSMA associated with both successful go responses and no-go inhibitions. In a go/no-go task, univariate analysis showed undifferentiated activation of preSMA in response to both go and no-go stimuli. However, when an anatomically-defined preSMA ROI was subjected to MVPA, a significant difference in the activation pattern encoded by go as compared to no-go stimuli was observed. These differences in preSMA activation are consistent with the ongoing maintenance and manipulation of stimulus-action representations.",
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Representation of response alternatives in human presupplementary motor area : Multi-voxel pattern analysis in a go/no-go task. / Fedota, John R.; Hardee, Jillian E.; Pérez-Edgar, Koraly; Thompson, James C.

In: Neuropsychologia, Vol. 56, No. 1, 01.04.2014, p. 110-118.

Research output: Contribution to journalArticle

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