Repression of drosophila photoreceptor cell fate through cooperative action of two transcriptional repressors yan and tramtrack

Zhi-chun Lai, Michael Fetchko, Ying Li

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The Drosophila yan gene encodes an E twenty-six (ETS) domain nuclear protein with a transcription repressor activity that can be downregulated through phosphorylation by mitogen-activated protein kinase (MAPK). Before photoreceptor precursor cells commit to a particular cell fate, Yan is required to maintain them in an undifferentiated state. We report here identification of tramtrack (ttk) mutations that act as dominant enhancers of yan. We show that ttk synergistically interacts with yan to inhibit the R7 photoreceptor cell fate. Since ttk products are nuclear proteins with zinc- finger DNA-binding motifs, yah and ttk represent two nuclear regulators essential for the control of cellular competence for neural differentiation. Reduction of either yah or ttk activity suppresses eye phenotypes of the kinase suppressor of ras (ksr) gene mutation, which is consistent with the involvement of yah and ttk in the Ras/MAPK pathway.

Original languageEnglish (US)
Pages (from-to)1131-1137
Number of pages7
JournalGenetics
Volume147
Issue number3
StatePublished - Nov 1 1997

Fingerprint

Photoreceptor Cells
Nuclear Proteins
Mitogen-Activated Protein Kinases
Drosophila
Suppressor Genes
Mutation
Nucleotide Motifs
ras Genes
Zinc Fingers
Mental Competency
Down-Regulation
Phosphorylation
Phenotype
Genes
KSR-1 protein kinase

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

@article{18b147d1cfde478185d6c1924b7167ff,
title = "Repression of drosophila photoreceptor cell fate through cooperative action of two transcriptional repressors yan and tramtrack",
abstract = "The Drosophila yan gene encodes an E twenty-six (ETS) domain nuclear protein with a transcription repressor activity that can be downregulated through phosphorylation by mitogen-activated protein kinase (MAPK). Before photoreceptor precursor cells commit to a particular cell fate, Yan is required to maintain them in an undifferentiated state. We report here identification of tramtrack (ttk) mutations that act as dominant enhancers of yan. We show that ttk synergistically interacts with yan to inhibit the R7 photoreceptor cell fate. Since ttk products are nuclear proteins with zinc- finger DNA-binding motifs, yah and ttk represent two nuclear regulators essential for the control of cellular competence for neural differentiation. Reduction of either yah or ttk activity suppresses eye phenotypes of the kinase suppressor of ras (ksr) gene mutation, which is consistent with the involvement of yah and ttk in the Ras/MAPK pathway.",
author = "Zhi-chun Lai and Michael Fetchko and Ying Li",
year = "1997",
month = "11",
day = "1",
language = "English (US)",
volume = "147",
pages = "1131--1137",
journal = "Genetics",
issn = "0016-6731",
publisher = "Genetics Society of America",
number = "3",

}

Repression of drosophila photoreceptor cell fate through cooperative action of two transcriptional repressors yan and tramtrack. / Lai, Zhi-chun; Fetchko, Michael; Li, Ying.

In: Genetics, Vol. 147, No. 3, 01.11.1997, p. 1131-1137.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Repression of drosophila photoreceptor cell fate through cooperative action of two transcriptional repressors yan and tramtrack

AU - Lai, Zhi-chun

AU - Fetchko, Michael

AU - Li, Ying

PY - 1997/11/1

Y1 - 1997/11/1

N2 - The Drosophila yan gene encodes an E twenty-six (ETS) domain nuclear protein with a transcription repressor activity that can be downregulated through phosphorylation by mitogen-activated protein kinase (MAPK). Before photoreceptor precursor cells commit to a particular cell fate, Yan is required to maintain them in an undifferentiated state. We report here identification of tramtrack (ttk) mutations that act as dominant enhancers of yan. We show that ttk synergistically interacts with yan to inhibit the R7 photoreceptor cell fate. Since ttk products are nuclear proteins with zinc- finger DNA-binding motifs, yah and ttk represent two nuclear regulators essential for the control of cellular competence for neural differentiation. Reduction of either yah or ttk activity suppresses eye phenotypes of the kinase suppressor of ras (ksr) gene mutation, which is consistent with the involvement of yah and ttk in the Ras/MAPK pathway.

AB - The Drosophila yan gene encodes an E twenty-six (ETS) domain nuclear protein with a transcription repressor activity that can be downregulated through phosphorylation by mitogen-activated protein kinase (MAPK). Before photoreceptor precursor cells commit to a particular cell fate, Yan is required to maintain them in an undifferentiated state. We report here identification of tramtrack (ttk) mutations that act as dominant enhancers of yan. We show that ttk synergistically interacts with yan to inhibit the R7 photoreceptor cell fate. Since ttk products are nuclear proteins with zinc- finger DNA-binding motifs, yah and ttk represent two nuclear regulators essential for the control of cellular competence for neural differentiation. Reduction of either yah or ttk activity suppresses eye phenotypes of the kinase suppressor of ras (ksr) gene mutation, which is consistent with the involvement of yah and ttk in the Ras/MAPK pathway.

UR - http://www.scopus.com/inward/record.url?scp=0030722710&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030722710&partnerID=8YFLogxK

M3 - Article

C2 - 9383057

AN - SCOPUS:0030722710

VL - 147

SP - 1131

EP - 1137

JO - Genetics

JF - Genetics

SN - 0016-6731

IS - 3

ER -