Repression of the β-amyloid gene in a Hox-3.1-producing cell line

S. M. Violette, C. S. Shashikant, J. M. Salbaum, H. G. Belting, J. C.H. Wang, F. H. Ruddle

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Mammalian homeobox genes are widely expressed in the developing central nervous system and are postulated to control developmental processes by regulating gene expression at the transcriptional level. In vitro studies have identified consensus DNA sequences that contain an ATTA core as sites for interaction with homeodomain proteins. Such elements have been found in the upstream regulatory region of the gene encoding β-amyloid precursor protein, which is associated with the neurological disorder Alzheimer disease. As the β-amyloid precursor protein gene is also expressed in the developing central nervous system and appears to play a role in cellular regulatory processes, we have examined the possibility that a homeobox gene product can regulate its transcription. We demonstrate by Northern blot analyses and transfection experiments that the expression of the β-amyloid precursor protein gene is decreased in cultured cells expressing the mouse homeobox gene Hox-3.1.

Original languageEnglish (US)
Pages (from-to)3805-3809
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number9
DOIs
StatePublished - 1992

All Science Journal Classification (ASJC) codes

  • General

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