Reproductive hormone levels in infants with cryptorchidism during postnatal activation of the pituitary-testicular axis

Julia S. Barthold, Jeanne Manson, Virginia Regan, Xiaoli Si, Sandra G. Hassink, Michael T. Coughlin, Peter A. Lee, Barry Kogan, Doug Canning

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Purpose: Testosterone and luteinizing hormone secretion is reportedly impaired in infants born with cryptorchidism. To better characterize this phenomenon, we studied a range of hormones that normally increase in boys during the first few months of life. Materials and Methods: A case-control study was conducted of boys with nonsyndromic cryptorchidism identified at birth (cases) and boys with descended testes presenting to the urology clinic without endocrine related concerns (controls). Blood was obtained at approximately 2 months of age and up to 3 urine samples were obtained at monthly intervals until age 120 days. Testosterone, estradiol, luteinizing hormone and follicle-stimulating hormone were measured in plasma and urine, and inhibin B, sex hormone-binding globulin (SHBG) and leptin were measured in plasma using standard assays. Data were analyzed using t tests with and without log transformation. Results: Of 20 cases 15 were unilaterally cryptorchid. Although 7 testes descended spontaneously, 2 became cryptorchid again during followup and, therefore, 15 boys required orchiopexy. Diagnoses of 26 controls included foreskin problems (15), prenatal hydronephrosis (4), penile torsion (2), ectopic kidney (1) and hydrocele (1). None of the plasma or urinary hormone measurements was significantly different between boys requiring orchiopexy and controls. Plasma SHBG and testosterone, SHBG, estradiol and leptin, and body mass index positively correlated, while testosterone and body mass index negatively correlated. Conclusions: We failed to identify any significant differences in hormone levels between controls and boys with cryptorchidism during activation of the pituitary-testicular axis in early infancy. These data suggest that impairment of this process may be uncommon in boys with nonsyndromic cryptorchidism.

Original languageEnglish (US)
Pages (from-to)1736-1741
Number of pages6
JournalJournal of Urology
Volume172
Issue number4 II
DOIs
StatePublished - Oct 2004

Fingerprint

Cryptorchidism
Hormones
Sex Hormone-Binding Globulin
Testosterone
Orchiopexy
Luteinizing Hormone
Leptin
Testis
Estradiol
Body Mass Index
Urine
Foreskin
Hydronephrosis
Urology
Follicle Stimulating Hormone
Case-Control Studies
Parturition
Kidney

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Barthold, J. S., Manson, J., Regan, V., Si, X., Hassink, S. G., Coughlin, M. T., ... Canning, D. (2004). Reproductive hormone levels in infants with cryptorchidism during postnatal activation of the pituitary-testicular axis. Journal of Urology, 172(4 II), 1736-1741. https://doi.org/10.1097/01.ju.0000138523.24337.be
Barthold, Julia S. ; Manson, Jeanne ; Regan, Virginia ; Si, Xiaoli ; Hassink, Sandra G. ; Coughlin, Michael T. ; Lee, Peter A. ; Kogan, Barry ; Canning, Doug. / Reproductive hormone levels in infants with cryptorchidism during postnatal activation of the pituitary-testicular axis. In: Journal of Urology. 2004 ; Vol. 172, No. 4 II. pp. 1736-1741.
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Barthold, JS, Manson, J, Regan, V, Si, X, Hassink, SG, Coughlin, MT, Lee, PA, Kogan, B & Canning, D 2004, 'Reproductive hormone levels in infants with cryptorchidism during postnatal activation of the pituitary-testicular axis', Journal of Urology, vol. 172, no. 4 II, pp. 1736-1741. https://doi.org/10.1097/01.ju.0000138523.24337.be

Reproductive hormone levels in infants with cryptorchidism during postnatal activation of the pituitary-testicular axis. / Barthold, Julia S.; Manson, Jeanne; Regan, Virginia; Si, Xiaoli; Hassink, Sandra G.; Coughlin, Michael T.; Lee, Peter A.; Kogan, Barry; Canning, Doug.

In: Journal of Urology, Vol. 172, No. 4 II, 10.2004, p. 1736-1741.

Research output: Contribution to journalArticle

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T1 - Reproductive hormone levels in infants with cryptorchidism during postnatal activation of the pituitary-testicular axis

AU - Barthold, Julia S.

AU - Manson, Jeanne

AU - Regan, Virginia

AU - Si, Xiaoli

AU - Hassink, Sandra G.

AU - Coughlin, Michael T.

AU - Lee, Peter A.

AU - Kogan, Barry

AU - Canning, Doug

PY - 2004/10

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N2 - Purpose: Testosterone and luteinizing hormone secretion is reportedly impaired in infants born with cryptorchidism. To better characterize this phenomenon, we studied a range of hormones that normally increase in boys during the first few months of life. Materials and Methods: A case-control study was conducted of boys with nonsyndromic cryptorchidism identified at birth (cases) and boys with descended testes presenting to the urology clinic without endocrine related concerns (controls). Blood was obtained at approximately 2 months of age and up to 3 urine samples were obtained at monthly intervals until age 120 days. Testosterone, estradiol, luteinizing hormone and follicle-stimulating hormone were measured in plasma and urine, and inhibin B, sex hormone-binding globulin (SHBG) and leptin were measured in plasma using standard assays. Data were analyzed using t tests with and without log transformation. Results: Of 20 cases 15 were unilaterally cryptorchid. Although 7 testes descended spontaneously, 2 became cryptorchid again during followup and, therefore, 15 boys required orchiopexy. Diagnoses of 26 controls included foreskin problems (15), prenatal hydronephrosis (4), penile torsion (2), ectopic kidney (1) and hydrocele (1). None of the plasma or urinary hormone measurements was significantly different between boys requiring orchiopexy and controls. Plasma SHBG and testosterone, SHBG, estradiol and leptin, and body mass index positively correlated, while testosterone and body mass index negatively correlated. Conclusions: We failed to identify any significant differences in hormone levels between controls and boys with cryptorchidism during activation of the pituitary-testicular axis in early infancy. These data suggest that impairment of this process may be uncommon in boys with nonsyndromic cryptorchidism.

AB - Purpose: Testosterone and luteinizing hormone secretion is reportedly impaired in infants born with cryptorchidism. To better characterize this phenomenon, we studied a range of hormones that normally increase in boys during the first few months of life. Materials and Methods: A case-control study was conducted of boys with nonsyndromic cryptorchidism identified at birth (cases) and boys with descended testes presenting to the urology clinic without endocrine related concerns (controls). Blood was obtained at approximately 2 months of age and up to 3 urine samples were obtained at monthly intervals until age 120 days. Testosterone, estradiol, luteinizing hormone and follicle-stimulating hormone were measured in plasma and urine, and inhibin B, sex hormone-binding globulin (SHBG) and leptin were measured in plasma using standard assays. Data were analyzed using t tests with and without log transformation. Results: Of 20 cases 15 were unilaterally cryptorchid. Although 7 testes descended spontaneously, 2 became cryptorchid again during followup and, therefore, 15 boys required orchiopexy. Diagnoses of 26 controls included foreskin problems (15), prenatal hydronephrosis (4), penile torsion (2), ectopic kidney (1) and hydrocele (1). None of the plasma or urinary hormone measurements was significantly different between boys requiring orchiopexy and controls. Plasma SHBG and testosterone, SHBG, estradiol and leptin, and body mass index positively correlated, while testosterone and body mass index negatively correlated. Conclusions: We failed to identify any significant differences in hormone levels between controls and boys with cryptorchidism during activation of the pituitary-testicular axis in early infancy. These data suggest that impairment of this process may be uncommon in boys with nonsyndromic cryptorchidism.

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