Rerouting the traffic from a virus perspective

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Viruses are important human and animal pathogens causing disease that affect global health and the economy. One outcome of many virus infections is the regulation of cellular trafficking machinery. Viral proteins recruit and interact with cellular trafficking proteins to divert the normal trafficking of key proteins or to induce the formation of novel membrane structures in the host cell. These alterations often increase replication efficiency by mislocalizing immune regulators or restriction factors ot by creating platforms for replication and assembly of new virus particles. Our knowledge of how viruses interact with the cellular trafficking machinery is still limited and furthering this understanding will be important for the future development of prophylactic and therapeutic treatments. This review provides a glimpse of the types of interplay between viral and cellular factors that result in a disruption of cellular trafficking or modifications to cellular membranes.

Original languageEnglish (US)
Pages (from-to)1845-1866
Number of pages22
JournalFrontiers in Bioscience - Landmark
Volume22
Issue number11
StatePublished - Jun 1 2017

Fingerprint

Protein Transport
Viruses
Membranes
Viral Proteins
Virus Diseases
Virion
Machinery
Membrane structures
Pathogens
Animals
Proteins
Health
Therapeutics
Global Health

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

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abstract = "Viruses are important human and animal pathogens causing disease that affect global health and the economy. One outcome of many virus infections is the regulation of cellular trafficking machinery. Viral proteins recruit and interact with cellular trafficking proteins to divert the normal trafficking of key proteins or to induce the formation of novel membrane structures in the host cell. These alterations often increase replication efficiency by mislocalizing immune regulators or restriction factors ot by creating platforms for replication and assembly of new virus particles. Our knowledge of how viruses interact with the cellular trafficking machinery is still limited and furthering this understanding will be important for the future development of prophylactic and therapeutic treatments. This review provides a glimpse of the types of interplay between viral and cellular factors that result in a disruption of cellular trafficking or modifications to cellular membranes.",
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Rerouting the traffic from a virus perspective. / Cruz, Linda; Buchkovich, Nicholas.

In: Frontiers in Bioscience - Landmark, Vol. 22, No. 11, 01.06.2017, p. 1845-1866.

Research output: Contribution to journalReview article

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AU - Buchkovich, Nicholas

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